Animal and Plant Proteins and Glucose Metabolism

Description

The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal vs plant and protein-rich whole foods vs protein isolates) on: i) liver and muscle insulin sensitivity; ii) the metabolic response to a meal, and iii) 24-h plasma concentration profiles of glucose, glucoregulatory hormones, and protein-derived metabolites purported to cause metabolic dysfunction.

Conditions

Metabolic Syndrome, Metabolic Syndrome, Protection Against, Glucose Metabolism Disorders

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Study Overview

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Study Details

Study overview

The goal of this proposal is to determine the effect of a high protein diet in which the increase in protein intake is derived from different sources (animal vs plant and protein-rich whole foods vs protein isolates) on: i) liver and muscle insulin sensitivity; ii) the metabolic response to a meal, and iii) 24-h plasma concentration profiles of glucose, glucoregulatory hormones, and protein-derived metabolites purported to cause metabolic dysfunction.

Animal and Plant Proteins and Glucose Metabolism

Animal and Plant Proteins and Glucose Metabolism

Condition
Metabolic Syndrome
Intervention / Treatment

-

Contacts and Locations

Columbia

University of Missouri School of Medicine, Columbia, Missouri, United States, 65212

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * age: ≥21 and ≤70 years;
  • * BMI: \>24.5 and \<32.5 kg/m2;
  • * habitual protein intake \<0.9 g/kg/day (assessed on 2 weekdays and 2 weekend days by using the HealthWatch 360 app); and
  • * weight stable (i.e., ≤3% change) and untrained (≤150 min of structured exercise/week) for at least 2 months before entering the study.
  • * prediabetes or type 2 diabetes;
  • * evidence of chronic kidney disease by medical history or laboratory tests (glomerular filtration rate \<60 ml/min/1.73 m2 or an albumin to creatinine ratio in urine ≥30 mg/g);
  • * vegetarians or vegans;
  • * intolerance or allergies to ingredients in the metabolic meal or intervention diet;
  • * take dietary supplements (e.g., pre- and probiotics, fiber, fish oil) or medications known to affect our study outcomes;
  • * received antibiotic or antifungal treatment (which affect the microbiome and therefore microbial metabolite production) 2 months before entering the study;
  • * consume tobacco products or excessive alcohol (women: \>14 drinks/week; men: \>21 drinks/week);
  • * evidence of significant organ system dysfunction or diseases (e.g., cirrhosis), and
  • * unwilling or unable to provide informed consent.

Ages Eligible for Study

21 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Missouri-Columbia,

Bettina Mittendorfer, PRINCIPAL_INVESTIGATOR, University of Missouri-Columbia

Study Record Dates

2025-04-25