Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy

Description

This study plans to evaluate the time course of inflammation in the brain after a moderate to severe traumatic brain injury using positron emission tomography (PET) brain imaging. Patients will undergo PET scans of the brain at two weeks and two months after injury to measure neuro-inflammation. The results of the PET scans will be analyzed and correlated with the risk of post-traumatic epilepsy.

Conditions

Epilepsy, Post-Traumatic

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Study Overview

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Study Details

Study overview

This study plans to evaluate the time course of inflammation in the brain after a moderate to severe traumatic brain injury using positron emission tomography (PET) brain imaging. Patients will undergo PET scans of the brain at two weeks and two months after injury to measure neuro-inflammation. The results of the PET scans will be analyzed and correlated with the risk of post-traumatic epilepsy.

Imaging of Glial Activation and Risk for Post-Traumatic Epilepsy

Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy

Condition
Epilepsy, Post-Traumatic
Intervention / Treatment

-

Contacts and Locations

Sacramento

University of California, Davis, Sacramento, California, United States, 95817

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Acute Traumatic Brain Injury (TBI)
  • * Age 18-100 are eligible
  • * Glasgow Coma Scale (GCS) 3-13 without continuous sedation at time of enrollment
  • * Ability to enroll within 72 hours of injury
  • * Hemorrhagic contusional injuries to frontal and/or temporal lobes.
  • * Polytrauma including long bone fractures, blunt trauma, abdominal trauma or similar will be allowed
  • * Penetrating TBI if continuous electroencephalography (cEEG) is feasible and survival for 2 years is feasible, recognizing that MRI may not be feasible with some forms of penetrating trauma
  • * Low-affinity TSPO binding profile
  • * Ages 17 years or younger
  • * Patients with diffuse axonal injury in the absence of hemorrhagic contusions or skull fracture, and isolated epidural hemorrhages that improve after evacuation
  • * No planned continuous EEG monitoring during injury day 1-7
  • * Inability to undergo MRI at 14 days (± 4 days) due to bullet, metal implant, or pacemaker
  • * Pregnancy
  • * Pre-existing Neurodegenerative Disorders
  • * Pre-existing epilepsy/seizure disorder
  • * Pre-existing dementia
  • * Isolated anoxic brain injury
  • * Incarceration present or pending
  • * Devastating cervical spine injury

Ages Eligible for Study

18 Years to 100 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Davis,

Study Record Dates

2025-08-14