Phenotyping Genetic Risk for Type 2 Diabetes

Description

This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.

Conditions

Diabetes Mellitus, Type 2, Genetics

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Study Overview

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Study Details

Study overview

This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.

Phenotyping Children and Adults With Possible High or Low Genetic Risk for Type 2 Diabetes

Phenotyping Genetic Risk for Type 2 Diabetes

Condition
Diabetes Mellitus, Type 2
Intervention / Treatment

-

Contacts and Locations

Philadelphia

Childrens Hospital of Philadelphia, Philadelphia, Pennsylvania, United States, 19104

Philadelphia

University of Pennsylvania, Philadelphia, Pennsylvania, United States, 19104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 10-70 years
  • * Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research.
  • * Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher
  • * prior diagnosis of type 1, type 2, or secondary diabetes
  • * use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication
  • * acute illness that may impact insulin and glucose dynamics
  • * pregnancy
  • * hypothalamic obesity or related genetic disorder of metabolism
  • * recent systemic chemotherapy use
  • * gastrointestinal impairment or surgery that may impact absorption
  • * anemia
  • * major organ system illness or any underlying condition requiring regular medication or treatment that could make implementation of the protocol or interpretation of the study results difficult
  • * inability to comply with study protocol

Ages Eligible for Study

10 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Pennsylvania,

Jessica R Wilson, MD, MS, PRINCIPAL_INVESTIGATOR, University of Pennsylvania

Lorraine Levitt Katz, MD, PRINCIPAL_INVESTIGATOR, Children's Hospital of Philadelphia

Study Record Dates

2026-06-30