Hyperpolarized Carbon 13-Based Metabolic Imaging to Detect Radiation-Induced Cardiotoxicity

Eligibility Criteria

• 1. Benign or malignant tumor of the breast (left-sided only) or thorax
• 2. Stage I to IV. If stage IV, patient must have life expectancy equal to or greater than 6 months
• 3. ECOG performance status 0-1
• 4. The patient must be deemed an appropriate candidate for standard of care radiation therapy
• 5. Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 90 days following completion of therapy. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately.
• 5.1 A female of child-bearing potential is any woman (regardless of sexual orientation, having undergone a tubal ligation, or remaining celibate by choice) who meets the following criteria:
• * Has not undergone a hysterectomy or bilateral oophorectomy; or
• * Has not been naturally postmenopausal for at least 12 consecutive months (i.e., has had menses at any time in the preceding 12 consecutive months).
• 5.2. A female of postmenopausal status is defined as patients over 60 or greater OR patients age 50-59 who meet the following criteria:
• * s/p bilateral oophorectomy, OR
• * with intact uterus without menses in the past 12 months OR,
• * with biochemical confirmation of post-menopausal status (estradiol in the menopausal range based on local laboratory criteria)
• 6. Ability to understand and the willingness to sign a written informed consent.
• 1. Prior radiation involving the heart
• 2. Subjects may not be receiving any known cardiotoxic agents for the 6 months prior to the study and during the study
• 3. Diagnosis of connective tissue disorders, including systemic lupus erythematosis, scleroderma, or dermatomyositis
• 4. Patients with stage IV cancer with life expectancy of less than 6 months
• 5. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that, in the opinion of the investigator, would limit compliance with study requirements
• 6. eGFR \<30
• 7. Any contraindication to MRI (including, but not limited to metal implants and devices contraindicated at 3T, breast tissue expanders, non-MR compatible IV port, claustrophobia)
• 8. History of psychiatric or addictive disorders that would preclude obtaining informed consent
• 9. Subjects must not be pregnant or nursing due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants.