rTMS in Alleviating Pain and Co-Morbid Symptoms in Gulf War Veterans Illness (GWVI)

Description

This study aims to look at the effectiveness of using repetitive transcranial magnetic stimulation (rTMS) in relieving pain and other co-morbid symptoms of Gulf War Illness.

Conditions

Gulf War Illness, Depression

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Study Overview

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Study Details

Study overview

This study aims to look at the effectiveness of using repetitive transcranial magnetic stimulation (rTMS) in relieving pain and other co-morbid symptoms of Gulf War Illness.

rTMS in Alleviating Pain and Co-morbid Symptoms in GWVI

rTMS in Alleviating Pain and Co-Morbid Symptoms in Gulf War Veterans Illness (GWVI)

Condition
Gulf War Illness
Intervention / Treatment

-

Contacts and Locations

Palo Alto

VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto, California, United States, 94304-1290

San Diego

VA San Diego Healthcare System, San Diego, CA, San Diego, California, United States, 92161-0002

Decatur

Atlanta VA Medical and Rehab Center, Decatur, GA, Decatur, Georgia, United States, 30033

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male or female under 65 years of age who served in the military for at least 30 consecutive days between August 1, 1990, and July 31, 1991 in the Persian Gulf War region
  • * CDC Criteria for GWVI (GWI)
  • * Kansas Criteria for GWVI (GWI)
  • * International Headache Society Criteria for Migraine Headache without aura
  • * Average Overall Daily Muscle Pain Intensity \>3 on 0-10 a NPS
  • * Average Overall Daily Extremities Joint Pain Intensity \>3 on 0-10 a NPS
  • * Headache Exacerbation/attack once a week with the average intensity \>3 on a 0-10 NPS, lasting \> 1 hour in the past three months
  • * Hamilton Rating Scale of Depression (HRSD) greater than or equal to 14 based on the sum of scores for the first 17 items
  • * Pregnancy
  • * History of pacemaker implant
  • * Any ferromagnetic (e.g. bullet fragment, shrapnel, device implant) in the brain or body that will prohibit the patients from having a brain MRI
  • * History of dementia, major psychiatric diseases, or life-threatening diseases
  • * Presence of any other chronic neuropathic pain states such as Complex Regional Pain Syndrome or Painful Peripheral Neuropathy
  • * History of seizure
  • * Pending litigation
  • * Low back pain with mechanical origins such as lumbar radiculopathy or radiculitis or lumbar facet arthropathy
  • * Lack of ability to understand the experimental protocol and to adequately communicate in English
  • * History of Traumatic Brain injury
  • * Chronic Tension or Cluster Headache
  • * Ongoing Cognitive Rehabilitation or Treatment of PTSD

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

VA Office of Research and Development,

Albert Yick Leung, MD, PRINCIPAL_INVESTIGATOR, VA San Diego Healthcare System, San Diego, CA

Study Record Dates

2025-09-30