Non-Invasive Quantification of Liver Health in NASH (N-QUAN)

Eligibility Criteria

• * Male and Female subjects aged between 18 and 75 years old
• * Ability to understand and sign a written informed consent forms
• * Patients scheduled to undergo a standard of care diagnostic liver biopsy as follows
• * Percutaneous biopsy with a 16 gauged needle passed into the right lobe
• * Trans-jugular biopsy with an 18 gauged needle passed into the right lobe
• * Patients who are suspected of having NAFLD, who are being considered for treatment, and presenting with two or more of the following risk factors for NASH
• * Elevated liver enzymes (ALT≥40)
• * BMI≥25kG/m\^2
• * Hypertension
• * Type II diabetes
• * Dyslipidameia
• * Low High-density lipoprotein (HDL) (\<40mg/dl in men or \<50mg/dl in women)
• * Hypertriglyceridemia (≥150mg/dl)
• * Hypercholestrolemia (≥200mg/dl)
• * Triglycerides (TG)/HDL\>5.0
• * Prior histopathological diagnosis of NASH
• * Inability to undergo a liver biopsy
• * Prior or planned liver transplantation
• * Patient scheduled to undergo a laparoscopic or wedge liver biopsy or biopsy taken from the left lobe
• * Participation in an investigational new drug (IND) trial in the 30 days before enrolment
• * Other known causes of chronic liver disease based on clinical criteria at the study site such as the following:
• * Alcoholic liver disease
• * Primary biliary cirrhosis
• * Primary sclerosing cholangitis
• * Autoimmune Hepatitis
• * Wilson's disease, hemochromatosis, iron overload
• * Alpha/1/Antitrypsin (A1AT) deficiency
• * HCV, HBV
• * History or diagnosis of cirrhosis and or hepatic decompensation including ascites, hepatic encephalopathy or variceal bleeding
• * Clinically relevant drug or alcohol abuse within 12 months of screening
• * Any contradiction or significant limitation to MRI scanning
• * Claustrophobia preventing MR imaging (requires 15-30 minutes in scanning)
• * Pacemaker or another implanted device
• * Metal in body (such as an aneurysm clip) that might produce artefacts on abdominal MRI or might be adversely impacted by a high magnetic field
• * Inability to lie flat, remain still or briefly hold breath as necessary during MR imaging
• * Medical condition likely to produce significant hypervolemia like congestive heart failure
• * Severe obesity complicating positioning in MR scanner
• * Weight reduction surgery within 3 years
• * Concomitant medical illnesses per investigators discretion (such as HIV infection, recent major surgery, uncontrolled heart disease, concurrent infection or fever of unknown origin, illicit drug use, cancer
• * Clinically significant medical or psychiatric condition considered a high risk participation in an investigational study
• * Failure to give informed consent