Brain metastases are a source of much morbidity and mortality in adults with primary solid malignant tumors. With improvements in systemic therapy that prolong survival but have limited central nervous system penetration, patients with brain metastases are at increasing risk of developing and experiencing long-term side effects from treatment of brain metastases. The overarching goal of this study is to better understand the determinants of RT-associated changes in white and gray matter function and associated neurocognitive decline.
Brain Metastases, Neurocognitive Deficit, White Matter Alterations, Radiation Exposure
Brain metastases are a source of much morbidity and mortality in adults with primary solid malignant tumors. With improvements in systemic therapy that prolong survival but have limited central nervous system penetration, patients with brain metastases are at increasing risk of developing and experiencing long-term side effects from treatment of brain metastases. The overarching goal of this study is to better understand the determinants of RT-associated changes in white and gray matter function and associated neurocognitive decline.
MRI Biomarkers for Radiation-Induced Neurocognitive Decline Following SRS of Newly Diagnosed Brain Mets
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University of North Carolina at Chapel Hill, Department of Radiation Oncology, Chapel Hill, North Carolina, United States, 27599
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
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18 Years to
ALL
No
UNC Lineberger Comprehensive Cancer Center,
Colette J Shen, MD, PhD, PRINCIPAL_INVESTIGATOR, University of North Carolina at Chapel Hill, Department of Radiation Oncology
Tong Zhu, PhD, DABR, PRINCIPAL_INVESTIGATOR, University of North Carolina at Chapel Hill, Department of Radiation Oncology
2026-09-15