Ashwagandha for Cognitive Dysfunction

Description

This is a 1:1 randomized double blinded placebo controlled trial. • To determine if ashwagandha can improve cognitive dysfunction when compared with placebo in patients undergoing chemotherapy for cancer.

Conditions

Chemo Fog

Talk to us

Study Overview

On this page

Study Details

Study overview

This is a 1:1 randomized double blinded placebo controlled trial. • To determine if ashwagandha can improve cognitive dysfunction when compared with placebo in patients undergoing chemotherapy for cancer.

A Randomized Placebo-controlled Trial of Ashwagandha (Withania Somnifera) for Cognitive Dysfunction Associated With Cancer Chemotherapy.

Ashwagandha for Cognitive Dysfunction

Condition
Chemo Fog
Intervention / Treatment

-

Contacts and Locations

Sacramento

Sutter Cancer Center, Sacramento, California, United States, 95816

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age 18 years and older
  • 2. English speaking
  • 3. Currently undergoing chemotherapy or treatment with chemotherapy in the past year
  • 4. Self-reported memory loss, attention, visual-spatial functioning, reasoning, or information processing or cognitive changes in the first 2 cycles of chemotherapy and score \< 63 on the FACT-Cog PCI
  • 5. Able to follow instructions for testing and comply with testing
  • 6. Able to swallow pills
  • 1. Undergoing treatment for any hormone dependent cancer
  • 2. Planned surgical treatment
  • 3. History of pre-existing dementia, untreated depression, psychiatric disorder, prior brain radiation or brain injury
  • 4. History of hypotension
  • 5. Active autoimmune disease
  • 6. Brain metastasis
  • 7. Taking any drugs daily that would alter cognition
  • 8. Concurrent use of benzodiazepenes or other sedatives
  • 9. Concurrent use of supplements that can cause sedation such as 5-HTP, calamus, California poppy, hops, Jamaican dogwood, kava, St.John's Wort, skullcap, valerian, yerba mansa
  • 10. Currently taking hypoglycemic medications
  • 11. History of substance abuse
  • 12. Current or recent diagnosis of stomach ulcer or gastritis

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Sutter Health,

Deepti Behl, MD, PRINCIPAL_INVESTIGATOR, Sutter Health

Carol Parise, PhD, STUDY_DIRECTOR, Sutter Health

Study Record Dates

2025-07-01