Mindfulness in Chronic Kidney Disease

Description

This study will test whether mindfulness meditation (MM) improves sympathetic function in chronic kidney disease (CKD) and whether transcutaneous vagus nerve stimulation (tVNS) optimizes the sympatho-inhibitory effects of mindfulness meditation (MM) and restores autonomic balance in CKD patients.

Conditions

Chronic Kidney Diseases

Talk to us

Study Overview

On this page

Study Details

Study overview

This study will test whether mindfulness meditation (MM) improves sympathetic function in chronic kidney disease (CKD) and whether transcutaneous vagus nerve stimulation (tVNS) optimizes the sympatho-inhibitory effects of mindfulness meditation (MM) and restores autonomic balance in CKD patients.

Sympatho-inhibition With Mindfulness in Chronic Kidney Disease (MIND-CKD)

Mindfulness in Chronic Kidney Disease

Condition
Chronic Kidney Diseases
Intervention / Treatment

-

Contacts and Locations

Atlanta

Atlanta VA Medical Center, Atlanta, Georgia, United States, 30322

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * stages III and IV CKD as defined by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine equation
  • * stable renal function (no greater than a decline of eGFR of 1 cc/min/1.73 m2 per month over the prior 3 months)
  • * severe CKD (eGFR\<15 cc/min)
  • * diabetic neuropathy
  • * autonomic dysfunction
  • * any serious disease that might influence survival
  • * anemia with hemoglobin \<10 g/dL
  • * treatment with central α-agonists or monoamine oxidase (MAO) inhibitors
  • * myocardial infarction or cerebrovascular accident within the past 6 months
  • * uncontrolled hypertension (BP≥170/100 mm Hg)
  • * low BP (BP\<100/50 mm Hg)
  • * bradycardia (HR\<55 beats/min)
  • * ongoing drug or alcohol abuse (defined as \>2 drinks/day in men, and \>1 drink/day in women)
  • * surgery within the past 3 months
  • * adjustment of antihypertensive medications within the past month
  • * pregnancy or plans to become pregnant
  • * psychosis
  • * suicidal ideation
  • * implanted electronic or metallic device such as a pacemaker
  • * implanted hearing aid, bone plate, carotid stent, bone screw at or near the neck
  • * carotid atherosclerosis
  • * concurrent use of another stimulating device such as a transcutaneous electrical nerve stimulation (TENS) unit.

Ages Eligible for Study

40 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Emory University,

Jeanie Park, PRINCIPAL_INVESTIGATOR, Emory University

Study Record Dates

2025-08