The Prehospital Airway Control Trial (PACT) is a proposed 5 year, open label, multi-center, stepped-wedge randomized trial comparing airway management strategies of prehospital trauma patients. The initial airway attempt will be randomized to either usual care (control) or a supraglottic airway management approach (intervention). The primary outcome will be 24 hour survival, with secondary outcomes to include survival to hospital discharge, expected clinical adverse events, airway management performance, ICU length of stay, ventilator days, incidence of ARDS, and incidence of ventilator associated pneumonia. Subjects will be enrolled across approximately 17 prehospital agencies at select LITES Network sites and will enroll a total of 2,009 subjects.
Trauma Injury, Airway Control
The Prehospital Airway Control Trial (PACT) is a proposed 5 year, open label, multi-center, stepped-wedge randomized trial comparing airway management strategies of prehospital trauma patients. The initial airway attempt will be randomized to either usual care (control) or a supraglottic airway management approach (intervention). The primary outcome will be 24 hour survival, with secondary outcomes to include survival to hospital discharge, expected clinical adverse events, airway management performance, ICU length of stay, ventilator days, incidence of ARDS, and incidence of ventilator associated pneumonia. Subjects will be enrolled across approximately 17 prehospital agencies at select LITES Network sites and will enroll a total of 2,009 subjects.
LITES Task Order 0005 Prehospital Airway Control Trial (PACT)
-
Emory University, Atlanta, Georgia, United States, 30303
Mount Sinai Hospital, Chicago, Illinois, United States, 60608
Northwestern Memorial Hospital, Chicago, Illinois, United States, 60611
John H. Stroger Hospital of Cook County, Chicago, Illinois, United States, 60612
University of Chicago, Chicago, Illinois, United States, 60637
University of Louisville, Louisville, Kentucky, United States, 40208
Tulane University, New Orleans, Louisiana, United States, 70112
Washington University at St. Louis, Saint Louis, Missouri, United States, 63110
East Carolina University, Greenville, North Carolina, United States, 27835
Oregon Health & Science University, Portland, Oregon, United States, 97239
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
15 Years to
ALL
No
Jason Sperry,
Jason Sperry, MD, MPH, PRINCIPAL_INVESTIGATOR, University of Pittsburgh
Francis Guyette, MD, MPH, PRINCIPAL_INVESTIGATOR, University of Pittsburgh
2026-03-31