This study plans to analyze the molecular and clinical mechanisms of the relationship between the GBA mutations and Parkinson's disease. This will be assessed through the use of advanced neuroimaging techniques called PET (positron emission tomography) to study the accumulation of the tau protein and the dysfunction of acetylcholine and dopamine in the brain of people with a mutation in the GBA gene, with and without Parkinson's disease. The ingestigators will also use a technology-based assessment to study the typing patterns as possible biomarkers of early motor dysfunctions.
Parkinson Disease, GBA Gene Mutation, Gaucher Disease
This study plans to analyze the molecular and clinical mechanisms of the relationship between the GBA mutations and Parkinson's disease. This will be assessed through the use of advanced neuroimaging techniques called PET (positron emission tomography) to study the accumulation of the tau protein and the dysfunction of acetylcholine and dopamine in the brain of people with a mutation in the GBA gene, with and without Parkinson's disease. The ingestigators will also use a technology-based assessment to study the typing patterns as possible biomarkers of early motor dysfunctions.
The GBA Multimodal Study in Parkinson's Disease
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Oregon Health & Science University, Portland, Oregon, United States, 97239
University of Washington, Seattle, Washington, United States, 98108-1595
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
18 Years to 80 Years
ALL
No
Pacific Parkinson's Research Centre,
Michele Matarazzo, MD, PRINCIPAL_INVESTIGATOR, Pacific Parkinson's Research Centre | University of British Columbia
A. Jon Stoessl, CM, MD, FRCPC, FCAHS, PRINCIPAL_INVESTIGATOR, Pacific Parkinson's Research Centre | University of British Columbia
2025-12-30