Looking at Cognitive and Brain Changes in People With Lymphoma Receiving CAR-T Therapy

Eligibility Criteria

• * Patients must be 18 years of age or older
• * Planned treatment with commercial CD19-specific CAR T cells (axicabtagene ciloleucel, tisagenlecleucel, lisocabtagene maraleucel, or brexacabtagene autoleucel) for lymphoma.
• * Patients must have adequate end organ function for CAR T cell therapy
• * Eastern Cooperative Group (ECOG) performance status of 0 to 2
• * Meet cardiac, pulmonary, hematologic, hepatic, and renal requirements for CART therapy as described in corresponding product package insert
• * No evidence of central nervous system disease at study entry
• * Fluent and able to communicate well enough in English to complete the study assessments and provide informed consent, in the judgment of the consenting professional. o Patients who report that English is not their primary language will be asked the US Census English proficiency question: "How well do you speak English," and the answer "very well" will be required
• * Signs and/or symptoms of central nervous system cancer (e.g., metastases, leptomeningeal disease) as determined by their physician, medical records, or by a brain MRI, either at the time of enrollment or during the study period.
• * Current diagnosis of major Axis I psychiatric disorder (DSM-IV), major depression, bipolar disorder, or schizophrenia, as per medical records or patient report
• * History of neurodegenerative disease, or traumatic brain injury with loss of consciousness (\>60 minutes), as per medical records or patient report
• * A history of epilepsy as per medical records or patient report
• * Current ongoing substance abuse and/or history of substance abuse, as per medical records or patient report
• * Evidence of visual or auditory impairment that would preclude completion of the assessments, as per medical records or patient report
• * Contraindications to MRI examinations as per standard screening guidelines used in the Department of Radiology (i.e., ferromagnetic material or implants, pacemakers or defibrillators, stents, claustrophobia)