Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell Anemia

Description

MitoQ is commercially available as a dietary supplement and it has been tested as a potential drug in other diseases, but it has never been tested in patients with sickle cell disease. The goal of this research is to study if MitoQ, a molecule that works as an antioxidant by removing potentially damaging agents in a living organism, improves platelet function in patients with sickle cell disease (SCD).

Conditions

Sickle Cell Disease

Study Overview

Study Details

Study overview

MitoQ is commercially available as a dietary supplement and it has been tested as a potential drug in other diseases, but it has never been tested in patients with sickle cell disease. The goal of this research is to study if MitoQ, a molecule that works as an antioxidant by removing potentially damaging agents in a living organism, improves platelet function in patients with sickle cell disease (SCD).

Effect of MitoQ on Platelet Function and Reactive Oxygen Species (ROS) Generation in Patients With Sickle Cell Anemia

Effect of MitoQ on Platelet Function and Reactive Oxygen Species Generation in Patients With Sickle Cell Anemia

Condition
Sickle Cell Disease
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

Magee Women's Hospital, Pittsburgh, Pennsylvania, United States, 15213

Pittsburgh

UPMC Montefiore, Pittsburgh, Pennsylvania, United States, 15213

Pittsburgh

UPMC Presbyterian, Pittsburgh, Pennsylvania, United States, 15213

Pittsburgh

Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States, 15224

Pittsburgh

Hillman Cancer Center, Pittsburgh, Pennsylvania, United States, 15232

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * African American
  • * Patients with sickle cell anemia
  • * 18 years old or older
  • * African American healthy controls
  • * 18 years of age or older
  • 1. Pregnancy,
  • 2. Known hypertension,
  • 3. Hemodialysis and active obstructive sleep apnea requiring treatment.
  • 4. Use of anti-platelet medication or have had transfusion in the 4 weeks prior to enrollment.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Pittsburgh,

Ramasubramanian Kalpatthi, MD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

2026-06-30