Exercise Plus Duloxetine for Knee Osteoarthritis

Description

This study evaluates the addition of duloxetine to aerobic exercise in the treatment of symptomatic knee osteoarthritis and depressive symptoms in adults. All participants will receive the receive the treatment protocol, which will first be evaluated in terms of feasibility and then pilot tested.

Conditions

Knee Osteoarthritis, Depression

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Study Overview

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Study Details

Study overview

This study evaluates the addition of duloxetine to aerobic exercise in the treatment of symptomatic knee osteoarthritis and depressive symptoms in adults. All participants will receive the receive the treatment protocol, which will first be evaluated in terms of feasibility and then pilot tested.

A Feasibility and Pilot Study of Combined Treatment Protocol Using Aerobic Exercise and Duloxetine in Older Adults With Symptomatic Knee Osteoarthritis and Comorbid Depression

Exercise Plus Duloxetine for Knee Osteoarthritis

Condition
Knee Osteoarthritis
Intervention / Treatment

-

Contacts and Locations

Baltimore

University of Maryland School of Medicine, Baltimore, Maryland, United States, 21201

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. English speaking
  • 2. 40 years or older
  • 3. Symptomatic knee osteoarthritis fulfilling 1986 American College of Rheumatology criteria
  • 4. No plan for surgical knee osteoarthritis intervention within six months of enrollment
  • 5. Major depressive disorder satisfying diagnostic criteria according to the DSM-V
  • 6. Ability to participate in a supervised aerobic exercise program
  • 1. Already performing aerobic or resistive exercise 2x/week or more
  • 2. Taking duloxetine, antipsychotics, benzodiazepines, or opioid analgesics
  • 3. Other medications deemed by study team to endanger the health of the participant or unduly confound the results
  • 4. Cognitive impairment (Mini-Mental State Examination score \< 20)
  • 5. Past or current bipolar disorder or psychotic symptoms according to the DSM-V
  • 6. Substance abuse disorder or suicidal ideation within the previous year
  • 7. Not able to participate in a supervised exercise program based on the presence of unstable angina, recent MI (within last 3 months), hemiparetic gait, inability to walk at least 1mph on treadmill safely, poorly controlled hypertension (resting blood pressure \> 190/110), peripheral arterial disease with current foot or leg ulcers, or cardiac or pulmonary disease with exercise tolerance NYHA class 3 or higher.
  • 8. Active cancer that is currently undergoing treatment (receiving chemotherapy and/or radiation therapy)
  • 9. Pregnant or lactating women
  • 10. Other conditions deemed by study team to endanger the health of the participant or unduly confound the results

Ages Eligible for Study

40 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Maryland, Baltimore,

Study Record Dates

2025-12-30