RECRUITING

DNA Repair Activity in the Skin of Day and Night Shift Workers

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to test how the skin of night shift workers responds to artificial sunlight (ultraviolet B radiation; UVB) at two different times of the day in comparison to normal day shift workers. After the skin biopsies are obtained, they will be brought to the laboratory to be exposed to UVB radiation and to measure UVB responses.

Official Title

Pilot Study on DNA Repair Activity in the Skin of Day and Night Shift Workers

Quick Facts

Study Start:2022-12-07
Study Completion:2025-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04122456

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 40 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Male/Female
  2. * Fair skin (Fitzpatrick types I and II)
  3. * Age 18 to 40
  4. * Able to comprehend procedures/risks
  5. * Primarily work and are awake during normal daylight hours (6 am to 6 pm), or primarily work and are awake during night shifts hours (between the hours of 6 pm and 6 am) or may work a mixture of these shifts over the past 3 months. Rotating shifts will be categorized based on the majority of hours worked on average during the last 3 months. Able to fill out a 3-month calendar of work schedule.
  1. * Known photosensitivity
  2. * Currently on photosensitizing medications
  3. * Diabetes Mellitus
  4. * On any hormonal agents (e.g., birth control pills)
  5. * History of abnormal scarring
  6. * History of skin infections
  7. * History of skin cancers
  8. * History of sleep disorders such as sleep apnea or insomnia
  9. * Known allergy to lidocaine local anesthetic
  10. * Pregnancy or nursing
  11. * Other serious health issues

Contacts and Locations

Study Contact

Manager, Clinical Research Operations
CONTACT
937-245-7500
pturesearch@wrightstatephysicians.org
Regulatory Specialist
CONTACT
937-245-7500
pturesearch@wrightstatephysicians.org

Principal Investigator

Jeffrey B Travers, MD, PhD
PRINCIPAL_INVESTIGATOR
Wright State University

Study Locations (Sites)

Wright State Physicians
Fairborn, Ohio, 45324
United States

Collaborators and Investigators

Sponsor: Wright State University

  • Jeffrey B Travers, MD, PhD, PRINCIPAL_INVESTIGATOR, Wright State University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-12-07
Study Completion Date2025-12

Study Record Updates

Study Start Date2022-12-07
Study Completion Date2025-12

Terms related to this study

Additional Relevant MeSH Terms

  • Skin Cancer