RECRUITING

Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This neuroimaging study is a clinical trial investigating the effectiveness of intermittent theta-burst transcranial magnetic stimulation (iTBS-TMS) to the inferior parietal lobule (IPL) in reducing suicide risk in patients with major depressive episode (MDE) or borderline personality disorder (BPD).

Official Title

Circuit-Based Approach to Suicide: Biomarkers, Predictors, and Novel Therapeutics

Quick Facts

Study Start:2023-11-01
Study Completion:2025-02-28
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04130958

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * 18-65 years of age
  2. * Diagnosed with BPD or MDE
  3. * Chief complaint of suicidal thoughts and behaviors
  1. * Neurological conditions with known structural brain lesion
  2. * Prior neurosurgical procedure
  3. * Metal in the body that is ferromagnetic or metal injury to the eyes
  4. * Epilepsy
  5. * Implanted pacemaker, medication pump, vagal stimulator, deep brain stimulator, TENS unit, or ventriculo-peritoneal shunt
  6. * Psychopathology not appropriate for the treatment (e.g., manic episode or psychosis)
  7. * Current alcohol dependence or active symptoms of non-alcohol psychoactive substance use withdrawal, as indicated by self-report
  8. * Inability to meet the safety criteria for MRI scanning according to the protocols of the MGH Department of Radiology
  9. * Current pregnancy

Contacts and Locations

Study Contact

DNN Inbox
CONTACT
6177248780
mghdnn@mgh.harvard.edu

Principal Investigator

Joan Camprodon, MD/PhD
PRINCIPAL_INVESTIGATOR
6177265348

Study Locations (Sites)

Massachusetts General Hospital
Boston, Massachusetts, 02129
United States

Collaborators and Investigators

Sponsor: Massachusetts General Hospital

  • Joan Camprodon, MD/PhD, PRINCIPAL_INVESTIGATOR, 6177265348

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-11-01
Study Completion Date2025-02-28

Study Record Updates

Study Start Date2023-11-01
Study Completion Date2025-02-28

Terms related to this study

Keywords Provided by Researchers

  • Transcranial Magnetic Stimulation
  • Intermittent Theta Burst

Additional Relevant MeSH Terms

  • Major Depressive Episode
  • Borderline Personality Disorder
  • Suicide