Carbon Dioxide (CO2) Chemosensitivity and SUDEP

Description

The purpose of this research study is to better understand what causes Sudden Unexpected Death in Epilepsy (SUDEP). This study will enroll subjects from the University of Iowa Hospitals and Clinics (UIHC) Epilepsy Monitoring Unit (EMU) and Epilepsy Clinics. The investigators will analyze the effects of seizures on breathing, on the cardiovascular system, and on arousal. The investigators are studying these effects because some cases of SUDEP might be due, in part, to an inability to wake up or sense elevated carbon dioxide (CO2) levels when breathing is impaired. Subjects will be followed for ten years after enrollment to monitor their health.

Conditions

Epilepsy, SUDEP

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Study Overview

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Study Details

Study overview

The purpose of this research study is to better understand what causes Sudden Unexpected Death in Epilepsy (SUDEP). This study will enroll subjects from the University of Iowa Hospitals and Clinics (UIHC) Epilepsy Monitoring Unit (EMU) and Epilepsy Clinics. The investigators will analyze the effects of seizures on breathing, on the cardiovascular system, and on arousal. The investigators are studying these effects because some cases of SUDEP might be due, in part, to an inability to wake up or sense elevated carbon dioxide (CO2) levels when breathing is impaired. Subjects will be followed for ten years after enrollment to monitor their health.

The Role of Central CO2 Chemosensitivity in Postictal Respiratory Depression and SUDEP

Carbon Dioxide (CO2) Chemosensitivity and SUDEP

Condition
Epilepsy
Intervention / Treatment

-

Contacts and Locations

Iowa City

University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States, 52242

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. The subject is between 18 and 99 years of age.
  • 2. Confirmed or suspected epilepsy.
  • 3. Admission to the EMU for spell characterization (EMU group) or undergoing care in the University of Iowa Health Care Epilepsy Clinic.
  • 1. History of uncontrolled cardiac, pulmonary, or hepatic disease.
  • 2. Progressive or uncontrolled neurologic disease unrelated to epilepsy.
  • 3. Current opioid use.
  • 4. Women of child-bearing potential who are pregnant or capable of becoming pregnant (e.g. sexual activity within the past 21 days without a highly effective form of birth control or positive urine pregnancy test).
  • 5. Other comorbid condition that may influence the safety or feasibility of HCVR testing.
  • 6. Limited decision-making capacity and absence of a qualified representative.

Ages Eligible for Study

18 Years to 99 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Iowa,

Brian Gehlbach, MD, PRINCIPAL_INVESTIGATOR, University of Iowa

George Richerson, MD, PhD, PRINCIPAL_INVESTIGATOR, University of Iowa

Study Record Dates

2029-10