VItamin C in Thermal injuRY: The VICToRY Trial

Description

This study aims to show that giving high dose, intravenous vitamin C in addition to standard care to burned critically ill patients will be associated with less organ dysfunction, improved survival and a quicker rate of recovery. In this study, all patients will receive standard care and of the patients will also receive high dose intravenous vitamin C, while the other half of patients will receive placebo.

Conditions

Shock, Thermal Burn

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Study Overview

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Study Details

Study overview

This study aims to show that giving high dose, intravenous vitamin C in addition to standard care to burned critically ill patients will be associated with less organ dysfunction, improved survival and a quicker rate of recovery. In this study, all patients will receive standard care and of the patients will also receive high dose intravenous vitamin C, while the other half of patients will receive placebo.

VItamin C in Thermal injuRY: The VICToRY Trial A Phase III Multi-center Randomized Trial

VItamin C in Thermal injuRY: The VICToRY Trial

Condition
Shock
Intervention / Treatment

-

Contacts and Locations

Phoenix

Arizona Burn Center Valleywise Health, Phoenix, Arizona, United States, 85008

Bridgeport

Bridgeport Hospital, Bridgeport, Connecticut, United States, 06610

Washington

MedStar Washington Hospital Center, Washington, District of Columbia, United States, 20010

Iowa City

University of Iowa Hospitals & Clinics, Iowa City, Iowa, United States, 52242

Saint Louis

Mercy Hospital St. Louis, Saint Louis, Missouri, United States, 63141

Ohio City

The Ohio State University Medical Center, Ohio City, Ohio, United States, 43210

Dallas

UT Southwestern Medical Center, Dallas, Texas, United States, 75390-8507

Houston

University of Texas Health Science Center - Houston, Houston, Texas, United States, 77030

Seattle

Harborview Medical Center - Seattle, Seattle, Washington, United States, 98104

Milwaukee

Ascension Columbia St. Mary's, Milwaukee, Wisconsin, United States, 53211

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18 years of age or older
  • * Deep 2nd and/or 3rd degree burns requiring skin grafting
  • * Minimum burn size of ≥ 20% Total Body Surface Area (TBSA)
  • * \>24 hours from admission to participating hospital to consent.
  • * Patients admitted to burn unit \>24 from injury or accident.
  • * Patients who are moribund (not expected to survive the next 72 hours).
  • * Pregnancy (pregnancy will be ruled out as part of standard of care) or lactating.
  • * Enrollment in another industry sponsored ICU intervention study.
  • * Receiving high-dose IV vitamin C already (enteral or oral vitamin C is allowed).
  • * Known glucose-6-phosphate dehydrogenase (G6PD) deficiency.
  • * Recent history of kidney stones (within the last year).
  • * Concomitant use of hydroxycobalamin (vitamin B12) for suspected cyanide poisoning.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Clinical Evaluation Research Unit at Kingston General Hospital,

Daren K Heyland, MD, PRINCIPAL_INVESTIGATOR, Queen's University

Study Record Dates

2027-06