Skeletal Muscle Energetics and Fatiguability in Older Individuals

Description

The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.

Conditions

HIV, HIV Infections

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Study Overview

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Study Details

Study overview

The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.

Skeletal Muscle Energetics and Fatiguability in Older Individuals

Skeletal Muscle Energetics and Fatiguability in Older Individuals

Condition
HIV
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins Hospital, Baltimore, Maryland, United States, 21287

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Participants who are \>= 60 years of age
  • * HIV serostatus positive participants on stable antiretroviral therapy (ART) (no regimen change in last month) with undetectable HIV viral load (\<100 copies).
  • * HIV serostatus negative participants
  • * Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent
  • * Contraindications to MRI
  • * Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease that significantly limits exercise capacity
  • * Significant lower extremity peripheral vascular disease.
  • * Weight greater than 350 lbs
  • * Cognitive or speech impairments that would limit completion of questionnaires or fatigue reporting.

Ages Eligible for Study

60 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Johns Hopkins University,

Robert G Weiss, MD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

2027-07-01