RECRUITING

Skeletal Muscle Energetics and Fatiguability in Older Individuals

Conditions

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.

Official Title

Skeletal Muscle Energetics and Fatiguability in Older Individuals

Quick Facts

Study Start:2019-01-03

Study Completion:2027-07-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT04142047

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:60 Years to 90 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Participants who are \>= 60 years of age * HIV serostatus positive participants on stable antiretroviral therapy (ART) (no regimen change in last month) with undetectable HIV viral load (\<100 copies). * HIV serostatus negative participants	* Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent * Contraindications to MRI * Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease that significantly limits exercise capacity * Significant lower extremity peripheral vascular disease. * Weight greater than 350 lbs * Cognitive or speech impairments that would limit completion of questionnaires or fatigue reporting.

Inclusion Criteria

Exclusion Criteria

* Participants who are \>= 60 years of age
* HIV serostatus positive participants on stable antiretroviral therapy (ART) (no regimen change in last month) with undetectable HIV viral load (\<100 copies).
* HIV serostatus negative participants

* Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent
* Contraindications to MRI
* Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease that significantly limits exercise capacity
* Significant lower extremity peripheral vascular disease.
* Weight greater than 350 lbs
* Cognitive or speech impairments that would limit completion of questionnaires or fatigue reporting.

Contacts and Locations

Study Contact

Maria Esteban, RN, BSN

CONTACT

410-955-1160

mesteba1@jh.edu

Tricia Steinberg, RN, MSN

CONTACT

443-287-3469

asteinb3@jhmi.edu

Principal Investigator

Robert G Weiss, MD

PRINCIPAL_INVESTIGATOR

Johns Hopkins University

Study Locations (Sites)

Johns Hopkins Hospital

Baltimore, Maryland, 21287

United States

Collaborators and Investigators

Sponsor: Johns Hopkins University

Robert G Weiss, MD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-01-03

Study Completion Date2027-07-01

Study Record Updates

Study Start Date2019-01-03

Study Completion Date2027-07-01

Terms related to this study

Additional Relevant MeSH Terms

HIV
HIV Infections