Promoting Activity and Cognitive Enrichment in Schizophrenia (PACES)

Description

This project will conduct a confirmatory efficacy trial of two novel psychosocial interventions, Cognitive Enhancement Therapy and Enriched Supportive Therapy, for the treatment of persistent negative symptoms in schizophrenia.

Conditions

Schizophrenia

Study Overview

Study Details

Study overview

This project will conduct a confirmatory efficacy trial of two novel psychosocial interventions, Cognitive Enhancement Therapy and Enriched Supportive Therapy, for the treatment of persistent negative symptoms in schizophrenia.

Cognitive Enhancement for Persistent Negative Symptoms in Schizophrenia

Promoting Activity and Cognitive Enrichment in Schizophrenia (PACES)

Condition
Schizophrenia
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. are between 18-60 years of age;
  • 2. have a diagnosis of schizophrenia or schizoaffective disorder confirmed by the SCID;
  • 3. have a clinical history of persistent negative symptoms lasting at least 3 months as identified from the medical record;
  • 4. have observed persistent negative symptoms at the beginning and end of the 4-week evaluation period;
  • 5. have been stabilized on antipsychotic medication at the beginning and end of the 4-week evaluation period;
  • 6. have stabilized depressive symptoms at the beginning and end of the 4-week evaluation period;
  • 7. have mild or absent extrapyramidal symptoms at the beginning and end of the 4-week evaluation period;
  • 8. have had changes to their primary antipsychotic medication within the previous 3 months;
  • 9. have current IQ \> 80; and
  • 10. are able to read (sixth grade level or higher) and speak fluent English. -
  • 1. the presence of organic brain syndrome;
  • 2. comorbid medical disorders producing cognitive impairment (e.g., mild brain injury, previous concussions with loss of consciousness);
  • 3. persistent suicidal or homicidal behavior;
  • 4. significant clinician-estimated medication non-adherence; and
  • 5. SCID-verified substance use disorder.

Ages Eligible for Study

18 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pittsburgh,

Study Record Dates

2025-06-30