Tissue Analysis After Tumor Ablation for Liver Metastases Leading to Immediate Retreatment

Description

This study will see whether collecting and analyzing needle biopsy samples from cancer liver metastases after a tumor ablation procedure will be able to identify cancer cells that are still alive. The results of these biopsies could help determine the next treatment for your cancer, but the biopsies could cause side effects.

Conditions

Liver Metastases

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Study Overview

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Study Details

Study overview

This study will see whether collecting and analyzing needle biopsy samples from cancer liver metastases after a tumor ablation procedure will be able to identify cancer cells that are still alive. The results of these biopsies could help determine the next treatment for your cancer, but the biopsies could cause side effects.

Clinical Trial Optimizing Tumor Ablation for Liver Metastases: Rapid Tissue Analysis Allowing for Immediate Retreatment; Metabolic Imaging Biomarker Validation; and Predictive Genetic Signatures

Tissue Analysis After Tumor Ablation for Liver Metastases Leading to Immediate Retreatment

Condition
Liver Metastases
Intervention / Treatment

-

Contacts and Locations

New York

Memorial Sloan Kettering Cancer Center, New York, New York, United States, 10065

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Diagnosis of liver metastases from various primary tumors
  • * Confined liver disease or limited extrahepatic disease stable/controlled for at least 4 months (extrahepatic disease amenable to treatment is allowed)
  • * Lesions of ≤3 cm in maximum diameter
  • * At least one FDG-avid lesion to be treated\*\*\*
  • * INR \< 1.5\*
  • * Platelet count ≥ 50,000
  • * Age \< 18
  • * Less than 5 mm distance to a structure (GI or biliary tract), that cannot be protected from ablation injury with technical modifications such as hydro or air dissection
  • * INR \> 1.5 that cannot be corrected with fresh frozen plasma \*\*
  • * Platelet count of \<50,000 that cannot be corrected with transfusion
  • * More than 3 tumors in the liver
  • * More than 5 tumors of extrahepatic disease (including mediastinal nodes and pulmonary nodules, abdominal or other lymph nodes, and bone metastasis)
  • * Presence of any peritoneal Carcinomatosis
  • * For patients on Coumadin, general clinical guidelines for IR ablation will be followed.
  • * For patients with no FDG-PET avid tumors aim 2 of the protocol will not be assessed

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Memorial Sloan Kettering Cancer Center,

Constantinos Sofocleous, MD, PhD, PRINCIPAL_INVESTIGATOR, Memorial Sloan Kettering Cancer Center

Study Record Dates

2026-10