ACTIVE_NOT_RECRUITING

Identification of Genetic Causes of Calcific Aortic Valve Disease

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Conditions

Calcific Aortic StenosisCalcific Aortic Stenosis - Bicuspid ValveAortic Valve DiseaseAortic Valve CalcificationAortic DiseasesAortic AneurysmAortic Valve Cusp AbnormalityAortic Valve Disease MixedAortic Valve Insufficiency

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.

Official Title

Identification of Genetic Causes of Calcific Aortic Valve Disease

Quick Facts

Study Start:2018-09-25
Study Completion:2027-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT04149600

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:20 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients with a plan to undergo elective aortic valve replacement and/or ascending aortic surgery
  1. * Age \< 20 years
  2. * Unable/unwilling to consent
  3. * History of aortic valve replacement or transcatheter aortic valve replacement (TAVR)
  4. * History of endocarditis
  5. * History of rheumatic fever
  6. * History of chest radiotherapy
  7. * History of organ transplant

Contacts and Locations

Study Locations (Sites)

Beth Israel Deaconess Medical Center
Boston, Massachusetts, 02215
United States

Collaborators and Investigators

Sponsor: Beth Israel Deaconess Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-09-25
Study Completion Date2027-06-30

Study Record Updates

Study Start Date2018-09-25
Study Completion Date2027-06-30

Terms related to this study

Additional Relevant MeSH Terms

  • Calcific Aortic Stenosis
  • Calcific Aortic Stenosis - Bicuspid Valve
  • Aortic Valve Disease
  • Aortic Valve Calcification
  • Aortic Diseases
  • Aortic Aneurysm
  • Aortic Valve Cusp Abnormality
  • Aortic Valve Disease Mixed
  • Aortic Valve Insufficiency