Identification of Genetic Causes of Calcific Aortic Valve Disease

Description

This study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.

Conditions

Calcific Aortic Stenosis, Calcific Aortic Stenosis - Bicuspid Valve, Aortic Valve Disease, Aortic Valve Calcification, Aortic Diseases, Aortic Aneurysm, Aortic Valve Cusp Abnormality, Aortic Valve Disease Mixed, Aortic Valve Insufficiency

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Study Overview

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Study Details

Study overview

This study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.

Identification of Genetic Causes of Calcific Aortic Valve Disease

Identification of Genetic Causes of Calcific Aortic Valve Disease

Condition
Calcific Aortic Stenosis
Intervention / Treatment

-

Contacts and Locations

Boston

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States, 02215

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients with a plan to undergo elective aortic valve replacement and/or ascending aortic surgery
  • * Age \< 20 years
  • * Unable/unwilling to consent
  • * History of aortic valve replacement or transcatheter aortic valve replacement (TAVR)
  • * History of endocarditis
  • * History of rheumatic fever
  • * History of chest radiotherapy
  • * History of organ transplant

Ages Eligible for Study

20 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Beth Israel Deaconess Medical Center,

Study Record Dates

2027-06-30