RH Genotype Matched RBC Transfusions

Description

To determine the feasibility and efficacy of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.

Conditions

Sickle Cells Disease

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Study Overview

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Study Details

Study overview

To determine the feasibility and efficacy of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.

RH Genotype Matched Red Cell Transfusions for Patients With Sickle Cell Disease

RH Genotype Matched RBC Transfusions

Condition
Sickle Cells Disease
Intervention / Treatment

-

Contacts and Locations

Philadelphia

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States, 19104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Subjects age \>6 months
  • * Diagnosis of SCD, all genotypes
  • * Require a period of chronic red cell transfusion therapy
  • * Subject/parental/guardian permission (informed consent) and if appropriate, child assent
  • * Rare RH genotype that would preclude identification of sufficient RBC units
  • * Antigen negative requirements due to alloimmunization that would preclude identification of sufficient RBC units
  • * Alloimmunized to D antigen
  • * Rh alloimmunized patients for whom providing RH genotype matched blood would expose the patient to an antigen that would not be consistent with standard of care and blood bank protocols
  • * Parents/guardians or subjects who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures

Ages Eligible for Study

6 Months to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Children's Hospital of Philadelphia,

Stella Chou, MD, PRINCIPAL_INVESTIGATOR, Children's Hospital of Philadelphia

Study Record Dates

2029-10