Non-pulmonary Contributors of Exercise Intolerance in Patients With Cystic Fibrosis

Description

The purpose of this research study is to examine if the use of antioxidant supplements impacts exercise intolerance in people with CF.

Conditions

Cystic Fibrosis

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Study Overview

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Study Details

Study overview

The purpose of this research study is to examine if the use of antioxidant supplements impacts exercise intolerance in people with CF.

Non-pulmonary Contributors of Exercise Intolerance in Patients With Cystic Fibrosis

Non-pulmonary Contributors of Exercise Intolerance in Patients With Cystic Fibrosis

Condition
Cystic Fibrosis
Intervention / Treatment

-

Contacts and Locations

Richmond

Virginia Commonwealth University, Richmond, Virginia, United States, 23298

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Diagnosis of CF
  • * Men and women (\> 18 yrs. old)
  • * FEV1 percent predicted \> 40%
  • * Patients with or without CF related diabetes
  • * Resting oxygen saturation (room air) \>90%
  • * Traditional CF-antioxidant medications
  • * Ability to perform reliable/reproducible PFTs
  • * Clinically stable for 4 weeks (no exacerbations or need for antibiotic antioxidant within 4 weeks of testing or major change in medical status)
  • * Pancreatic sufficient and pancreatic insufficient patients
  • * Children 17 years old and younger
  • * FEV1\<40% predicted
  • * Resting O2 saturation \<90%
  • * Clinical diagnosis of heart disease
  • * Clinical diagnosis of PAH
  • * Febrile illness within 4 weeks of a study visit
  • * Antioxidant for pulmonary exacerbation within 4 weeks of a study visit
  • * Currently smoking, pregnant or nursing
  • * Vasoactive medications (i.e. nitrates, beta-blockers, Viagra etc.)
  • * Patients with B. Cepacia

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Virginia Commonwealth University,

Paula Rodriguez Miguelez, PhD, PRINCIPAL_INVESTIGATOR, Virginia Commonwealth University

Study Record Dates

2025-01