Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon

Description

The investigators aim to determine if early operative intervention is superior to non-operative management for adult patients with computerized tomography (CT)-proven complicated appendicitis with phlegmon or abscess.

Conditions

Appendicitis

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Study Overview

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Study Details

Study overview

The investigators aim to determine if early operative intervention is superior to non-operative management for adult patients with computerized tomography (CT)-proven complicated appendicitis with phlegmon or abscess.

Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon

Operative Versus Non-Operative Management for Appendicitis With Abscess or Phlegmon

Condition
Appendicitis
Intervention / Treatment

-

Contacts and Locations

New Haven

Yale New Haven Hospital, New Haven, Connecticut, United States, 06512

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Complicated appendicitis with presumed perforation on (computer tomography) CT scan AND phlegmon or abscess greater than 2 centimeter (cm).
  • 1. Antibiotic therapy greater than 24 hours prior to considering for enrollment.
  • 2. Attempted drainage before randomization
  • 3. Pregnancy
  • 4. Antibiotic allergy requiring the use of something other than a beta-lactam or quinolone based therapy.
  • 5. Previous major intra-abdominal surgery by laparotomy
  • 6. Hospitalization within 2 weeks of randomization
  • 7. Presence of septic shock on admission.
  • 8. Mechanical ventilation
  • 9. Acute renal failure requiring dialysis

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Yale University,

Study Record Dates

2026-12-31