RECRUITING

Assessment of Corneal Endothelial Function Following Hypoxic Stress

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to determine the difference in the cornea's response to contact lens placement between healthy and unhealthy eyes. The amount of corneal swelling (corneal thickness) between normal and FECD patients before and after a stress test will be measured and compared.

Official Title

Assessment of Corneal Endothelial Function Following Hypoxic Stress

Quick Facts

Study Start:2024-12
Study Completion:2026-11-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04175938

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Have a clinical diagnosis of Fuchs endothelial corneal dystrophy
  2. * Be scheduled for corneal transplantation in the next 6 months
  3. * Have no history of prior ocular surgery in study eye
  4. * Have no history of contact lens intolerance
  5. * Be motivated and willing to complete ocular imaging tests
  6. * Have no prior history of ocular disease including ocular surface disease or glaucoma
  7. * Have no history of prior ocular surgery in study eye
  8. * Have no history of contact lens intolerance
  9. * Be motivated and willing to complete ocular imaging tests
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Stacey M Ellender, PhD
CONTACT
617-573-5507
stacey_ellender@meei.harvard.edu
Amy Quinkert, PhD
CONTACT
617-573-6060
amy_Quinkert@meei.harvard.edu

Study Locations (Sites)

Massachusetts Eye and Ear Infirmary
Boston, Massachusetts, 02114
United States

Collaborators and Investigators

Sponsor: Massachusetts Eye and Ear Infirmary

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-12
Study Completion Date2026-11-30

Study Record Updates

Study Start Date2024-12
Study Completion Date2026-11-30

Terms related to this study

Keywords Provided by Researchers

  • Fuch's Dystrophy, FECD, Fuch's Endothelial Corneal Dystrophy

Additional Relevant MeSH Terms

  • Fuchs' Endothelial Corneal Dystrophy