Assessment of Corneal Endothelial Function Following Hypoxic Stress

Description

The purpose of this study is to determine the difference in the cornea's response to contact lens placement between healthy and unhealthy eyes. The amount of corneal swelling (corneal thickness) between normal and FECD patients before and after a stress test will be measured and compared.

Conditions

Fuchs' Endothelial Corneal Dystrophy

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Study Overview

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Study Details

Study overview

The purpose of this study is to determine the difference in the cornea's response to contact lens placement between healthy and unhealthy eyes. The amount of corneal swelling (corneal thickness) between normal and FECD patients before and after a stress test will be measured and compared.

Assessment of Corneal Endothelial Function Following Hypoxic Stress

Assessment of Corneal Endothelial Function Following Hypoxic Stress

Condition
Fuchs' Endothelial Corneal Dystrophy
Intervention / Treatment

-

Contacts and Locations

Boston

Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, United States, 02114

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Have a clinical diagnosis of Fuchs endothelial corneal dystrophy
  • * Be scheduled for corneal transplantation in the next 6 months
  • * Have no history of prior ocular surgery in study eye
  • * Have no history of contact lens intolerance
  • * Be motivated and willing to complete ocular imaging tests
  • * Have no prior history of ocular disease including ocular surface disease or glaucoma
  • * Have no history of prior ocular surgery in study eye
  • * Have no history of contact lens intolerance
  • * Be motivated and willing to complete ocular imaging tests

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Massachusetts Eye and Ear Infirmary,

Study Record Dates

2026-11-30