Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy

Description

The purpose of this study is to determine a grading system for inflammation in lumbar disc herniation and which groups, if any, benefit most from the administration of an intra-operative epidural steroid.

Conditions

Lumbar Disc Herniation

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Study Overview

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Study Details

Study overview

The purpose of this study is to determine a grading system for inflammation in lumbar disc herniation and which groups, if any, benefit most from the administration of an intra-operative epidural steroid.

Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy for Herniated Lumbar Discs Is There a Role? - A Randomized Control Trial

Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy

Condition
Lumbar Disc Herniation
Intervention / Treatment

-

Contacts and Locations

Columbia

Missouri Orthopaedic Institute, Columbia, Missouri, United States, 65202

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Presenting to the University of Missouri hospital system - including the University of Missouri Hospital and Missouri Orthopaedic Institute - with a clinical assessment indicative of a lumbar disc herniation
  • * Failed conservative treatment - rest, anti-inflammatory medications, physical therapy
  • * Radiculopathy present - positive tension signs or sensory/motor neurologic deficits present
  • * Recent MRI confirming single-level lumbar disc herniation corresponding to clinical evaluation
  • * Concomitant spinal stenosis, segmental instability, or spondylolisthesis
  • * Previous surgery at the affected level or recurrent herniation
  • * Underlying disease that may affect response to steroids - immunocompromise, use of chronic steroids or immunosuppression
  • * Pregnancy - qualitative human chorionic gonadotropin (hCG) testing will be performed prior to enrollment
  • * Diagnosis of or symptoms concerning for cauda equina syndrome

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Missouri-Columbia,

Don Kim Moore, MD, PRINCIPAL_INVESTIGATOR, Missouri Orthopaedic Institute

Study Record Dates

2025-10