RECRUITING

Recovery of Bladder and Sexual Function After Human Spinal Cord Injury

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study will incorporate critical cross viscero-visceral intersystem interactions to 1) investigate in a controlled laboratory setting and then with mobile at-home monitoring the extent, severity, and frequency of occurrence of autonomic dysreflexia with respect to daily bladder and bowel function, in conjunction with identifying potential underlying mechanisms by examining urinary biomarkers for several specific vasoactive hormones, and 2) to regulate cardiovascular function therapeutically as part of bladder and bowel management using spinal cord epidural stimulation.

Official Title

Effects of Activity-Dependent Plasticity on Recovery of Bladder and Sexual Function After Human Spinal Cord Injury

Quick Facts

Study Start:2021-01-04
Study Completion:2027-01-03
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04193709

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 70 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * At least 18 years of age;
  2. * AIS A to D;
  3. * Neurogenic bladder and bowel dysfunction;
  4. * Stable medical condition
  1. * Prior Botox injections of the bladder and/or bladder augmentation surgery;
  2. * Colostomy bag,
  3. * Ventilator dependent;
  4. * Any implanted pump (i.e. Baclofen pump, pain pump, etc.);
  5. * Pregnant at the time of enrollment or planning to become pregnant during the time course of the study

Contacts and Locations

Study Contact

Charles Hubscher, PhD
CONTACT
502-852-3058
charles.hubscher@louisville.edu

Principal Investigator

Charles Hubscher, PhD
PRINCIPAL_INVESTIGATOR
University of Louisville

Study Locations (Sites)

University of Louisville
Louisville, Kentucky, 40202
United States

Collaborators and Investigators

Sponsor: University of Louisville

  • Charles Hubscher, PhD, PRINCIPAL_INVESTIGATOR, University of Louisville

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-01-04
Study Completion Date2027-01-03

Study Record Updates

Study Start Date2021-01-04
Study Completion Date2027-01-03

Terms related to this study

Additional Relevant MeSH Terms

  • Urinary Bladder, Neurogenic
  • Blood Pressure
  • Autonomic Dysreflexia
  • Bowel Incontinence