Effect of Giving Reduced Fluid in Children After Trauma

Description

This study is designed to help decide how much intravenous (IV) fluid should be given to pediatric trauma patients. No standard currently exists for managing fluids in critically ill pediatric trauma patients, and many fluid strategies are now in practice. For decades, trauma patients got high volumes of IV fluid. Recent studies in adults show that patients actually do better by giving less fluid. The investigators do not know if this is true in children and this study is designed to answer that question and provide guidelines for IV fluid management in children after trauma.

Conditions

Critical Illness, Pediatrics, General Surgery, Fluid Therapy, Wounds and Injuries

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Study Overview

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Study Details

Study overview

This study is designed to help decide how much intravenous (IV) fluid should be given to pediatric trauma patients. No standard currently exists for managing fluids in critically ill pediatric trauma patients, and many fluid strategies are now in practice. For decades, trauma patients got high volumes of IV fluid. Recent studies in adults show that patients actually do better by giving less fluid. The investigators do not know if this is true in children and this study is designed to answer that question and provide guidelines for IV fluid management in children after trauma.

Effect of Restricted Fluid Management Strategy on Outcomes in Critically Ill Pediatric Trauma Patients: A Multicenter Randomized Controlled Trial

Effect of Giving Reduced Fluid in Children After Trauma

Condition
Critical Illness
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins University Charlotte R. Bloomberg Children's Center, Baltimore, Maryland, United States, 21205

New York

Columbia University Irving Medical Center NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, New York, United States, 10032

Queens

Northwell Health Cohen Children's Medical Center, Queens, New York, United States, 11040

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Trauma patients older than 6 months and younger than 15 years admitted to the pediatric intensive care unit (PICU)
  • * Patients admitted to the PICU directly from the Emergency Department (ED)
  • * Patients admitted to the PICU from the operating room (OR)
  • * Patients transferred to PICU from outside facility ED (need to have been in ED 12 hours or less)
  • * Patients transferred to PICU from outside PICU or inpatient floor
  • * Patients transferred to PICU from outside facility ED if \>12 hours
  • * Patients expected to be discharged from the PICU within 24 hours
  • * Patient with congenital heart disease as defined by a congenital cardiac defect requiring surgery or medication
  • * Patient with diagnosis of chronic cardiac condition (e.g. hypertension, cardiac arrhythmia)
  • * Patients with chronic kidney disease as defined by an abnormality of kidney structure or function, present for more than 3 months, with implications to health
  • * Post-operative transplant, cardiac, and neurosurgical patients
  • * Patients with traumatic brain injury
  • * Patients with any disease that may affect baseline blood pressure and heart rate (endocrine disorders, certain genetic disorders, mitochondrial diseases)
  • * Hypotension requiring vasopressor therapy
  • * If massive transfusion protocol initiated

Ages Eligible for Study

6 Months to 15 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Columbia University,

Vincent P Duron, MD, PRINCIPAL_INVESTIGATOR, Columbia University

Study Record Dates

2026-09