The participants of this study will have advanced epithelioid sarcoma. Sarcoma is a cancer of the connective tissues, such as nerves, muscles and bones. Epithelioid sarcoma is an ultra-rare sarcoma of the soft-tissue. Part 1 of this trial will evaluate the safety and the level of the study drug that the study drug combinations can be tolerated (known as tolerability). It is also designed to establish a recommended study drug dosage for the next part of the study. Part 2 will evaluate and compare for each of the study drug combinations how long participants live without their disease getting worse. The study drug is called tazemetostat. The study will test tazemetostat in combination with doxorubicin compared to placebo (dummy treatment) in combination with doxorubicin. Doxorubicin is a current front line treatment for epithelioid sarcoma
Advanced Soft-tissue Sarcoma, Advanced Epithelioid Sarcoma
The participants of this study will have advanced epithelioid sarcoma. Sarcoma is a cancer of the connective tissues, such as nerves, muscles and bones. Epithelioid sarcoma is an ultra-rare sarcoma of the soft-tissue. Part 1 of this trial will evaluate the safety and the level of the study drug that the study drug combinations can be tolerated (known as tolerability). It is also designed to establish a recommended study drug dosage for the next part of the study. Part 2 will evaluate and compare for each of the study drug combinations how long participants live without their disease getting worse. The study drug is called tazemetostat. The study will test tazemetostat in combination with doxorubicin compared to placebo (dummy treatment) in combination with doxorubicin. Doxorubicin is a current front line treatment for epithelioid sarcoma
Tazemetostat in Combination With Doxorubicin as Frontline Therapy for Advanced Epithelioid Sarcoma
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City of Hope Comprehensive Cancer Center, Duarte, California, United States, 91010
Sarcoma Oncology Research Center, Santa Monica, California, United States, 90403
University of Colorado Hospital - Anschutz Cancer Pavilion, Aurora, Colorado, United States, 80045
Sarah Cannon Research Institute at HealthONE, Denver, Colorado, United States, 80218
Mayo Clinic-Jacksonville, Jacksonville, Florida, United States, 32224
Massachusetts General Hospital, Boston, Massachusetts, United States, 02214
Dana Farber Cancer Insititute, Boston, Massachusetts, United States, 02215
Dana Farber Cancer Institute, Boston, Massachusetts, United States, 02215
University of Michigan Medical Center, Ann Arbor, Michigan, United States, 48109
Washington University, Saint Louis, Missouri, United States, 63110
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
18 Years to
ALL
No
Epizyme, Inc.,
Ipsen Medical Director, STUDY_DIRECTOR, Ipsen
2030-01-01