Transcranial Magnetic Stimulation to Improve Functioning in Veterans With PTSD

Description

Posttraumatic Stress Disorder (PTSD) is a common and serious condition affecting many Veterans. There are effective treatments for PTSD, but additional treatments are needed in order to better serve Veterans suffering from PTSD. Transcranial magnetic stimulation is one such promising treatment. It involves use of powerful magnet to stimulate the specific brain regions in Veterans with PTSD. Transcranial magnetic stimulation has been shown effective in treating depression, but currently it is unclear if it is an effective treatment for PTSD. This is a randomized clinical trial enrolling 91 Veterans with PTSD comparing the effectiveness of transcranial magnetic stimulation treatment and sham transcranial magnetic stimulation in treating PTSD. The hypothesis is that those who receive transcranial magnetic stimulation will experience improved functioning.

Conditions

PTSD

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Study Overview

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Study Details

Study overview

Posttraumatic Stress Disorder (PTSD) is a common and serious condition affecting many Veterans. There are effective treatments for PTSD, but additional treatments are needed in order to better serve Veterans suffering from PTSD. Transcranial magnetic stimulation is one such promising treatment. It involves use of powerful magnet to stimulate the specific brain regions in Veterans with PTSD. Transcranial magnetic stimulation has been shown effective in treating depression, but currently it is unclear if it is an effective treatment for PTSD. This is a randomized clinical trial enrolling 91 Veterans with PTSD comparing the effectiveness of transcranial magnetic stimulation treatment and sham transcranial magnetic stimulation in treating PTSD. The hypothesis is that those who receive transcranial magnetic stimulation will experience improved functioning.

Transcranial Magnetic Stimulation to Improve Functioning in Veterans With PTSD

Transcranial Magnetic Stimulation to Improve Functioning in Veterans With PTSD

Condition
PTSD
Intervention / Treatment

-

Contacts and Locations

White River Junction

White River Junction VA Medical Center, White River Junction, VT, White River Junction, Vermont, United States, 05001-3833

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age between 19 and 70
  • 2. Moderate to severe PTSD as determined by the CAPS within 7 days of randomization.
  • 3. Agree to have CAPS audio-recorded.
  • 4. Ability to obtain a Motor Threshold using the TMS device during screening.
  • 5. Patient eligible for VA healthcare.
  • 6. If female with childbearing potential, use of acceptable method of birth control (i.e., use of contraceptives, abstinence).
  • 7. Able to read, understand, and sign the informed consent document.
  • 1. Pregnant or lactating woman.
  • 2. Current use of clozapine (any dose) or bupropion (more than 300mg per day).
  • 3. Cardiac pacemaker or implantable defibrillator.
  • 4. Presence of any metal object in the head, including cochlear implants, but excluding dental work in the mouth.
  • 5. Significant central nervous system disorder (stroke, brain mass, epilepsy).
  • 6. Seizure in past one year.
  • 7. Current psychosis or mania.
  • 8. Prior use of TMS.
  • 9. Significant suicidal ideation.
  • 10. Unstable medical conditions.
  • 11. Current alcohol or substance use disorder (except nicotine) that interferes with the patient's ability to participate.
  • 12. CPT or PE for PTSD in the past 2 months.
  • 13. Changes in Fluoxetine, Paroxetine, Sertraline, or Venlafaxine in the past 2 months.

Ages Eligible for Study

19 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

VA Office of Research and Development,

Bradley V Watts, MD MPH, PRINCIPAL_INVESTIGATOR, White River Junction VA Medical Center, White River Junction, VT

Study Record Dates

2024-09-30