SUSPENDED

Neoadjuvant Chemoradiation for Resectable Glioblastoma

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Preoperative therapy has not been well studied in resectable glioblastoma. This study attempts to prospectively assess the feasibility and efficacy of preoperative chemo radiation in improving local control, as this is the predominant mode of failure in these patients leading to poor outcomes. This Phase II study design would be used to proceed with the study treatment after meeting pre-specified events in the initial phase, with goal being to determine whether the new treatment paradigm is sufficiently promising to warrant a major controlled clinical evaluation against the standard therapy.

Official Title

Phase II Study of Neoadjuvant Chemoradiation for Resectable Glioblastoma (NeoGlio)

Quick Facts

Study Start:2020-04-01

Study Completion:2026-12-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:SUSPENDED

Study ID

NCT04209790

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 89 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Newly diagnosed GBM with histopathological confirmation. 2. Surgically suitable for subtotal or gross total resection as determined by central review. 3. Karnofsky Performance Status (KPS)\>70 4. No contraindication for chemoradiation. 5. Complete blood count (CBC)/differential obtained within 28 days prior to registration, with adequate bone marrow function defined as follows: 1. Absolute neutrophil count (ANC) ≥ 1,500 cells/mm3; 2. Platelets ≥ 100,000 cells/mm3; 3. Hemoglobin ≥ 8.0 g/dl (Note: the use of transfusion or other intervention to achieve Hgb ≥8.0 g/dl is acceptable) 6. Adequate hepatic function within 28 days prior to registration, as defined below: 1. Alanine Aminotransferase (ALT) and Aspartate transaminase (AST) ≤ 3 x ULN 2. Bilirubin ≤ 1.5 upper limit of normal (ULN) 7. Negative serum pregnancy test obtained for females of child-bearing potential within 28 days prior to step 2 registration. 8. Ability to get multiplanar contrast enhanced Magnetic Resonance Imaging (MRI)	1. Recurrent, unresectable or multifocal malignant gliomas. 2. Any site of distant disease (for example, drop metastases from the GBM tumor site) 3. Prior radiation or chemotherapy or radiosensitizers for cancers of the brain and head and neck region; note that prior chemotherapy for a different cancer is allowable (except temozolomide). 4. Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception; this exclusion is necessary because the treatment involved in this study may be significantly teratogenic. 5. Patents treated on any other therapeutic clinical protocols within 30 days prior to registration. 6. Inability to undergo MRI (e.g., due to safety reasons, such as presence of a pacemaker, or severe claustrophobia). 7. Severe, active co-morbidity, defined as follows: 1. Transmural myocardial infarction within the last 6 months prior to registration 2. History of recent myocardial infarction 1month prior 3. New York Heart Association grade II or greater congestive heart failure requiring hospitalization within 3 months prior to registration. 4. Serious or non-healing wound, ulcer or bone fracture or history of abdominal fistula, intra-abdominal abscess requiring major surgical procedure, open biopsy or significant traumatic injury within 28 days prior to registration, with the exception of the craniotomy for surgical resection 5. Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration 6. Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; note, however, that laboratory tests for coagulation parameters are not required for entry into this protocol. 7. Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration 8. Acquired immune deficiency syndrome (AIDS) based upon current Center for Disease Control (CDC) definition; note, however, that HIV testing is not required for entry into this protocol. The need to exclude patients with AIDS from this protocol is because the treatments involved in this protocol may be significantly immunosuppressive with potentially fatal outcomes in patients already immunosuppressed. 9. Any other severe immuno-compromised condition. 10. Active connective tissue disorders, such as lupus or scleroderma that in the opinion of the treating physician may put the patient at high risk for radiation toxicity. 11. End-stage renal disease (i.e. on dialysis or dialysis has been recommended). 12. Any other major medical illnesses or psychiatric treatments that in the investigator's opinion will prevent administration or completion of protocol therapy.

Inclusion Criteria

Exclusion Criteria

1. Newly diagnosed GBM with histopathological confirmation.
2. Surgically suitable for subtotal or gross total resection as determined by central review.
3. Karnofsky Performance Status (KPS)\>70
4. No contraindication for chemoradiation.
5. Complete blood count (CBC)/differential obtained within 28 days prior to registration, with adequate bone marrow function defined as follows:
1. Absolute neutrophil count (ANC) ≥ 1,500 cells/mm3;
2. Platelets ≥ 100,000 cells/mm3;
3. Hemoglobin ≥ 8.0 g/dl (Note: the use of transfusion or other intervention to achieve Hgb ≥8.0 g/dl is acceptable)
6. Adequate hepatic function within 28 days prior to registration, as defined below:
1. Alanine Aminotransferase (ALT) and Aspartate transaminase (AST) ≤ 3 x ULN
2. Bilirubin ≤ 1.5 upper limit of normal (ULN)
7. Negative serum pregnancy test obtained for females of child-bearing potential within 28 days prior to step 2 registration.
8. Ability to get multiplanar contrast enhanced Magnetic Resonance Imaging (MRI)

1. Recurrent, unresectable or multifocal malignant gliomas.
2. Any site of distant disease (for example, drop metastases from the GBM tumor site)
3. Prior radiation or chemotherapy or radiosensitizers for cancers of the brain and head and neck region; note that prior chemotherapy for a different cancer is allowable (except temozolomide).
4. Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception; this exclusion is necessary because the treatment involved in this study may be significantly teratogenic.
5. Patents treated on any other therapeutic clinical protocols within 30 days prior to registration.
6. Inability to undergo MRI (e.g., due to safety reasons, such as presence of a pacemaker, or severe claustrophobia).
7. Severe, active co-morbidity, defined as follows:
1. Transmural myocardial infarction within the last 6 months prior to registration
2. History of recent myocardial infarction 1month prior
3. New York Heart Association grade II or greater congestive heart failure requiring hospitalization within 3 months prior to registration.
4. Serious or non-healing wound, ulcer or bone fracture or history of abdominal fistula, intra-abdominal abscess requiring major surgical procedure, open biopsy or significant traumatic injury within 28 days prior to registration, with the exception of the craniotomy for surgical resection
5. Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration
6. Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; note, however, that laboratory tests for coagulation parameters are not required for entry into this protocol.
7. Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration
8. Acquired immune deficiency syndrome (AIDS) based upon current Center for Disease Control (CDC) definition; note, however, that HIV testing is not required for entry into this protocol. The need to exclude patients with AIDS from this protocol is because the treatments involved in this protocol may be significantly immunosuppressive with potentially fatal outcomes in patients already immunosuppressed.
9. Any other severe immuno-compromised condition.
10. Active connective tissue disorders, such as lupus or scleroderma that in the opinion of the treating physician may put the patient at high risk for radiation toxicity.
11. End-stage renal disease (i.e. on dialysis or dialysis has been recommended).
12. Any other major medical illnesses or psychiatric treatments that in the investigator's opinion will prevent administration or completion of protocol therapy.

Contacts and Locations

Principal Investigator

Michel Lacroix, M.D.

PRINCIPAL_INVESTIGATOR

Geisinger Clinic

Study Locations (Sites)

Geisinger Medical Center

Danville, Pennsylvania, 17822

United States

Geisinger Wyoming Valley Medical Center

Wilkes-Barre, Pennsylvania, 18711

United States

Collaborators and Investigators

Sponsor: Geisinger Clinic

Michel Lacroix, M.D., PRINCIPAL_INVESTIGATOR, Geisinger Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-04-01

Study Completion Date2026-12-31

Study Record Updates

Study Start Date2020-04-01

Study Completion Date2026-12-31

Terms related to this study

Keywords Provided by Researchers

Glioblastoma

Additional Relevant MeSH Terms

Glioblastoma
Surgery
High Grade Glioma