Biomarkers of Increased Free Living Sleep Time

Description

This protocol will increase sleep duration in participants who maintain less than 6 hours sleep per night, to target the recommended 7 hours of sleep per night. The focus of this study is determine how increasing nightly sleep duration in these individuals who maintain less than 6 hours sleep per night changes their plasma metabolome and insulin sensitivity. The primary outcome will examine changes in branched-chain amino acids and the secondary outcome will examine changes in insulin sensitivity. The investigators will also determine if changes in plasma metabolites can be used as a biomarker to discriminate between adequate versus insufficient sleep.

Conditions

Sleep Deprivation, Insufficient Sleep Syndrome, Sleep Wake Disorders

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Study Overview

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Study Details

Study overview

This protocol will increase sleep duration in participants who maintain less than 6 hours sleep per night, to target the recommended 7 hours of sleep per night. The focus of this study is determine how increasing nightly sleep duration in these individuals who maintain less than 6 hours sleep per night changes their plasma metabolome and insulin sensitivity. The primary outcome will examine changes in branched-chain amino acids and the secondary outcome will examine changes in insulin sensitivity. The investigators will also determine if changes in plasma metabolites can be used as a biomarker to discriminate between adequate versus insufficient sleep.

Biomarkers and Altered Metabolic Pathways During Sleep Loss

Biomarkers of Increased Free Living Sleep Time

Condition
Sleep Deprivation
Intervention / Treatment

-

Contacts and Locations

Salt Lake City

Sleep Wake Center--University of Utah, Salt Lake City, Utah, United States, 84108

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. 18-35 years old; men and women
  • 2. Body Mass Index (BMI) of \> 18.5 and \<24.9.
  • 3. Inactive to habitual moderate physical activity level (\<5 days of exercise per week).
  • 4. Sleep/wake history: habitual sleep duration less than 6 hours per night.
  • 5. Altitude history: Potential participants must have lived at Denver altitude or higher for at least 3 months.
  • 1. Any clinically significant unstable medical or surgical condition within the last year (treated or untreated).
  • 2. Any clinically significant psychiatric condition, as defined by DSM-IV-TR. I
  • 3. Any clinically significant sleep disorder.
  • 4. Use of prescription medications/supplements within one month or need of these medications at any time during the study.
  • 5. Symptoms of active illness (e.g., fever).
  • 6. Uncorrected visual impairment
  • 7. History of shift work in prior year or travel more than one time zone in three weeks prior to study.
  • 8. Participants must be entirely drug-free of illicit drugs, medications, nicotine and herbal products for one month prior to study.
  • 9. Blood donation in the 30 days prior to inpatient study.
  • 10. Ovulating women will be selected on the basis of a history of regular menstrual cycle ranging in length from 25-32 days with a maximum of three days variation month-to-month. They will have no history of prior gynecological pathology, be at least 1 year post-partum, not breast-feeding and not pregnant (HCG pregnancy test at screening and upon admission to the inpatient protocol).

Ages Eligible for Study

18 Years to 35 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Utah,

Christopher Depner, PRINCIPAL_INVESTIGATOR, University of Utah

Study Record Dates

2024-07-31