Semantic Feature Analysis Treatment for Aphasia

Description

This randomized controlled comparative effectiveness study examines manipulation of a key component of an established and efficacious treatment for naming impairments in aphasia, along with cognitive and brain correlates of treatment success. Study participants will be randomly assigned to one of two treatment conditions comparing two different versions of Semantic Feature Analysis treatment. Their performance on standardized and study-specific measures will be used to determine which version of the treatment provides superior outcomes, and measures of automatic language processing and functional brain imaging will also be used to identify the underlying neurocognitive mechanisms associated with positive treatment response.

Conditions

Aphasia

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Study Overview

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Study Details

Study overview

This randomized controlled comparative effectiveness study examines manipulation of a key component of an established and efficacious treatment for naming impairments in aphasia, along with cognitive and brain correlates of treatment success. Study participants will be randomly assigned to one of two treatment conditions comparing two different versions of Semantic Feature Analysis treatment. Their performance on standardized and study-specific measures will be used to determine which version of the treatment provides superior outcomes, and measures of automatic language processing and functional brain imaging will also be used to identify the underlying neurocognitive mechanisms associated with positive treatment response.

Optimizing and Understanding Semantic Feature Analysis Treatment for Aphasia: A Randomized Controlled Comparative Effectiveness Trial

Semantic Feature Analysis Treatment for Aphasia

Condition
Aphasia
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

VA Pittsburgh Healthcare System, Pittsburgh, Pennsylvania, United States, 15240

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 6 months post-onset of aphasia due to unilateral left-hemisphere (LH) stroke
  • * Independent in activities of daily living (ADLs) necessary to live in community-based housing or available caregiver to assist with ADLs
  • * Medically stable and able to tolerate intensive treatment schedule (e.g. no uncontrolled seizures, difficulty breathing, frequent migraines)
  • * English as a first language
  • * No participation in any other speech-language treatment during this study, including follow-up period
  • * Sufficient auditory comprehension abilities demonstrated during screening
  • * Sufficient naming impairment exhibited during screening
  • * Right Hemisphere stroke
  • * Neurological disease other than stroke
  • * Significant psychiatric disorder
  • * Severe motor speech disorder
  • * Active substance dependence

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

VA Pittsburgh Healthcare System,

William D Hula, Ph.D., PRINCIPAL_INVESTIGATOR, VA Pittsburgh Healthcare System

Patrick J Doyle, Ph.D., PRINCIPAL_INVESTIGATOR, VA Pittsburgh Healthcare System

Study Record Dates

2025-08-30