Effect of Vitamin D Status and Repletion on Postoperative Total Joint Arthroplasty Complications

Description

Vitamin D status has been shown to have an effect on post-operative outcomes in total joint arthroplasty. The goal of this study is to determine if pre-operative supplementation and correction of Vitamin D deficiency can reduce postoperative complications.

Conditions

Hip Arthropathy, Knee Arthropathy, Vitamin D Deficiency

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Study Overview

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Study Details

Study overview

Vitamin D status has been shown to have an effect on post-operative outcomes in total joint arthroplasty. The goal of this study is to determine if pre-operative supplementation and correction of Vitamin D deficiency can reduce postoperative complications.

Effect of Vitamin D Status and Repletion on Postoperative Total Joint Arthroplasty Complications

Effect of Vitamin D Status and Repletion on Postoperative Total Joint Arthroplasty Complications

Condition
Hip Arthropathy
Intervention / Treatment

-

Contacts and Locations

Boston

Brigham and Women's Hospital, Boston, Massachusetts, United States, 02115

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adult patients ≥18 years of age undergoing elective unilateral primary TJA for osteoarthritis
  • * Patients with a pre-operative serum 25(OH)D levels ≥10 ng/mL
  • * Patients who consent to the study
  • * Adult patients ≥18 years of age undergoing elective primary TJA with a pre-operative serum 25(OH)D2,3 level \<10 ng/mL
  • * Patients undergoing revision surgery
  • * Patients lacking mental capacity to comply with study procedures
  • * Patients with serum 25(OH)D levels between 10-29 ng/dL refusing to stop their current Vitamin D and multivitamins supplementations
  • * Hypercalcemia (total calcium \>10.6 mg/dL or ionized serum calcium \>5.4mg/dL)
  • * History of nephrolithiasis
  • * Granulomatous disease
  • * Dialysis and advanced kidney disease
  • * Previous infection/septic arthritis
  • * Inability to swallow Vitamin D3 pills
  • * Allergy to Vitamin D3 (It is estimated that 1 in 300 individuals may have an allergy with skin manifestations 17)
  • * Hypocalcemia (\<8.5 mg/dL)
  • * Chronic kidney disease (eGFR \<60 mL/minute)
  • * Known hyperparathyroidism
  • * Known osteoporosis/insufficiency stress fractures (if normal stresses are applied to an abnormal bone)
  • * Pregnancy

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Brigham and Women's Hospital,

Antonia F Chen, MD, PRINCIPAL_INVESTIGATOR, Brigham and Women's Hospital

Study Record Dates

2024-07-01