Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity

Description

This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin resistance.

Conditions

Obesity, Morbid, NASH - Nonalcoholic Steatohepatitis, Chronic Inflammation

Study Overview

Study Details

Study overview

This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin resistance.

Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity- AIM 1

Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity

Condition
Obesity, Morbid
Intervention / Treatment

-

Contacts and Locations

Scottsdale

Mayo Clinic in Arizona, Scottsdale, Arizona, United States, 85259

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Undergoing gastric bypass surgery
  • * Confirmed AUROC F=0 or F\>2 liver fibrosis
  • * Age 30-70 years
  • * BMI greater than 40 kg/m2
  • * Negative pregnancy test (female only)
  • * Lab Values: Normal TSH
  • * Autoimmune diseases
  • * Hepatitis B or C positive
  • * Heavy alcohol use
  • * Active smoking history
  • * Active cancer history
  • * History of asthma
  • * History of COPD
  • * Taking Plavix or Coumadin
  • * Blood donation within past 2 months
  • * Glucocorticoid Therapy
  • * Taking antihistamine on regular basis

Ages Eligible for Study

30 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Mayo Clinic,

Elena Anna O De Filippis, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2025-07