Physiological Effects of ANGPTL3 Variants in Humans

Eligibility Criteria

• * Subjects aged 18 or older meeting at least one of the following criteria
• 1. Carrying genetic variants in the gene encoding for ANGPTL3,
• 2. Unaffected controls matched for age, race, gender,
• 3. Willing to follow study procedures
• 4. Able to provide inform consent
• * Any medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
• * Taking any medication that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
• * Women that are pregnant or nursing
• * History of liver disease or abnormal liver function tests (\>2x upper limit of normal)
• * History of kidney disease or chronic renal insufficiency (eGFR \<60 mL/min/1.73 m2)
• * Uncontrolled hypertension (\>160/100 mmHg)
• * Uncontrolled diabetes
• * Anemia (hemoglobin \<11.0 mg/dL) History of a non-skin malignancy within the previous 5 years Major surgery within the past 3 months
• * History of any organ transplant
• * History of alcohol or drug abuse
• * Participation in clinical trials assessing the efficacy and safety of drugs affecting lipid metabolism within the past 6 weeks (or longer depending on the known half-life of the drug) that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study, or confound the study data
• * Inability to comply to study procedures