The Influence of Honey-flavored Yogurt on Low-grade Inflammation and Gut Health in Middle to Older Aged Women.

Description

A randomized, double-blind, crossover dietary intervention trial will test the effects of 4 weeks of daily honey-flavored yogurt intake on markers of inflammation (Th17 cytokines) and oxidative stress (NOX2, UA, RSNO) and associative changes with microbial derived metabolites (SCFAs, BAs, ellagitannins), metabolism and the fecal microbiome. The above suite of selected markers will capture diet-induced systemic changes in inflammation and oxidative stress, while assessing associated microbial changes.

Conditions

Overweight

Study Overview

Study Details

Study overview

A randomized, double-blind, crossover dietary intervention trial will test the effects of 4 weeks of daily honey-flavored yogurt intake on markers of inflammation (Th17 cytokines) and oxidative stress (NOX2, UA, RSNO) and associative changes with microbial derived metabolites (SCFAs, BAs, ellagitannins), metabolism and the fecal microbiome. The above suite of selected markers will capture diet-induced systemic changes in inflammation and oxidative stress, while assessing associated microbial changes.

The Influence of Honey-flavored Yogurt on Low-grade Inflammation and Gut Health in Middle to Older Aged Women.

The Influence of Honey-flavored Yogurt on Low-grade Inflammation and Gut Health in Middle to Older Aged Women.

Condition
Overweight
Intervention / Treatment

-

Contacts and Locations

Davis

University of California, Davis; Department of Nutrition, Davis, California, United States, 95616

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Postmenopausal female: 45-65 years
  • * Women: lack of menses for at least two years.
  • * Subject is willing and able to comply with the study protocols.
  • * Subject is willing to participate in all study procedures
  • * BMI 25.0 - 30.0 kg/m2
  • * BMI ≥ 31 kg/m2
  • * Food allergies
  • * Self-reported use of daily anticoagulation agents including aspirin, NSAIDs
  • * Vegan, Vegetarians, food faddists or those consuming a non-traditional diet
  • * Use of concentrated food supplements/powders and extracts
  • * Fruit consumption \> 2 cups/day
  • * Vegetable consumption \>3 cups/day
  • * Self-reported restriction of physical activity due to a chronic health condition
  • * Self-reported chronic/routine high intensity exercise
  • * Self-reported diabetes
  • * Blood pressure ≥ 140/90 mm Hg
  • * Self-reported renal or liver disease
  • * Self-reported heart disease, which includes cardiovascular events and stroke
  • * Abnormal Metabolic or CBC panels (laboratory values outside the reference range) if determined to be clinically significant by the study physician.
  • * Self-reported cancer within past 5 years
  • * Self-reported malabsorption
  • * Currently taking prescription drugs or supplements.
  • * Supplement use other than a general formula of vitamins and minerals that meet the RDA
  • * Not willing to stop any supplement use, including herbal, plant or botanical, fish oil, oil supplements a month prior to study enrollment.
  • * Indications of substance or alcohol abuse within the last 3 years
  • * Cannabis use
  • * Screening LDL ≥ 190 mg/dl for those who have 0-1 major risk factors apart from LDL cholesterol (i.e. family history of premature coronary artery disease (male first degree relative \< 55 years; CHD in female first degree relative \< 65 years), cigarette smoker, HDL-C ≤ 40 mg/dL\]. (using NCEP calculator http://cvdrisk.nhlbi.nih.gov/calculator.asp)
  • * Screening LDL ≥ 160 mg/dl for those who have 2 major risk factors apart from LDL cholesterol \[i.e. family history of premature coronary artery disease (male first degree relative \< 55 years; CHD in female first degree relative \< 65 years), cigarette smoker, HDL-C ≤ 40 mg/dL\]. (using NCEP calculator http://cvdrisk.nhlbi.nih.gov/calculator.asp);
  • * Screening LDL ≥ 130 mg/dl for those who have 2 major risk factors apart from LDL cholesterol \[i.e. family history of premature coronary artery disease (male first degree relative \< 55 years; CHD in female first degree relative \< 65 years), cigarette smoker, HDL-C ≤ 40 mg/dL\], and a Framingham 10-year Risk Score 10-20% (using NCEP calculator http://cvdrisk.nhlbi.nih.gov/calculator.asp).
  • * Current enrollee in a clinical research study.

Ages Eligible for Study

45 Years to 65 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of California, Davis,

Carl L Keen, PhD, PRINCIPAL_INVESTIGATOR, University of California, Davis; Department of Nutrition

Study Record Dates

2024-12-31