RECRUITING

A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

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Conditions

Ovarian Carcinoma

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study may help doctors determine if the two surgical procedures are nearly the same for ovarian cancer risk reduction for women with BRCA1 mutations.

Official Title

A Non-Randomized Prospective Clinical Trial Comparing the Non-Inferiority of Salpingectomy to Salpingo-oophorectomy to Reduce the Risk of Ovarian Cancer Among BRCA1 Carriers [SOROCk]

Quick Facts

Study Start:2020-09-01
Study Completion:2037-06-23
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04251052

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:35 Years to 50 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Individuals 35-50 years of age, inclusive
  2. * Patients who will undergo risk-reducing salpingo-oophorectomy (RRSO) (for the BSO arm) and patients who have declined or elected to defer BSO after proper counselling to clearly explain the standard of care for BRCA1 mutation carriers and are undergoing salpingectomy (for the BLS arm with delayed oophorectomy arm). Concurrently planned hysterectomy with either arm is permitted
  3. * At least one intact ovary and fallopian tube is in situ at the time of counseling, consent, and registration. Prior hysterectomy is allowed provided it did not include bilateral salpingectomy. Prior tubal ligation is allowed if one ovary and fallopian tube (with fimbria not removed) are present
  4. * Positive Clinical Laboratory Improvement Act (CLIA)-approved test results for pathogenic or likely pathogenic germline BRCA1 mutation in the patient. Documentation of the result is required
  5. * Patients may be premenopausal or menopausal
  6. * Pelvic ultrasound (transvaginal imaging preferred, but transabdominal imaging is acceptable) and CA-125 within 180 days of registration
  7. * The patient or a legally authorized representative must provide study-specific informed consent prior to study entry
  8. * Individuals who are currently pregnant or plan to become pregnant in the future through assisted reproductive technologies and who have received proper counseling are eligible. Individuals who are currently pregnant and plan bilateral salpingectomy at the time of a planned cesarean section are eligible. Patients must understand that they will not be able to become pregnant naturally in the future
  1. * Individuals with a history of any prior cancer who have received cytotoxic chemotherapy within the past 30 days or radiotherapy to abdomen or pelvis at any prior time. Endocrine therapy or maintenance ERBB2/HER2 targeted therapy is allowed. Maintenance immune checkpoint inhibitor therapy is allowed. Maintenance therapy with PARP in inhibitor is allowed.
  2. * Prior history of ovarian cancer, including low malignant potential neoplasms (LMP), primary peritoneal carcinoma, or fallopian tube carcinoma
  3. * Patients medically unfit for the planned surgical procedure
  4. * Patients with abnormal screening tests (pelvic ultrasound, CA-125) suspicious for occult or gross pelvic malignancy within the past 180 days
  5. * An abnormal pelvic ultrasound is defined as morphologic or structural variations suspicious for ovarian malignancy. Complex cystic lesions felt to represent a benign lesion are not exclusionary. Simple cysts of any size are not exclusionary
  6. * An abnormal CA-125 is defined as a level \> 50U/ml in premenopausal individuals if they are not current users of oral contraceptives; an abnormal CA-125 is defined as a level \> 40U/ml for premenopausal individuals who are current users of oral contraceptives (Skates 2011). An abnormal CA-125 is defined as a level \> 35 U/ml in postmenopausal individuals

Contacts and Locations

Principal Investigator

Kathryn P Pennington
PRINCIPAL_INVESTIGATOR
NRG Oncology

Study Locations (Sites)

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233
United States
Anchorage Associates in Radiation Medicine
Anchorage, Alaska, 98508
United States
Anchorage Radiation Therapy Center
Anchorage, Alaska, 99504
United States
Alaska Breast Care and Surgery LLC
Anchorage, Alaska, 99508
United States
Alaska Oncology and Hematology LLC
Anchorage, Alaska, 99508
United States
Alaska Women's Cancer Care
Anchorage, Alaska, 99508
United States
Katmai Oncology Group
Anchorage, Alaska, 99508
United States
Providence Alaska Medical Center
Anchorage, Alaska, 99508
United States
CTCA at Western Regional Medical Center
Goodyear, Arizona, 85338
United States
Banner University Medical Center - Tucson
Tucson, Arizona, 85719
United States
University of Arizona Cancer Center-North Campus
Tucson, Arizona, 85719
United States
Kaiser Permanente-Deer Valley Medical Center
Antioch, California, 94531
United States
Tower Cancer Research Foundation
Beverly Hills, California, 90211
United States
Keck Medicine of USC Buena Park
Buena Park, California, 90621
United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California, 91505
United States
City of Hope Comprehensive Cancer Center
Duarte, California, 91010
United States
Kaiser Permanente Dublin
Dublin, California, 94568
United States
Kaiser Permanente-Fremont
Fremont, California, 94538
United States
Fresno Cancer Center
Fresno, California, 93720
United States
Kaiser Permanente-Fresno
Fresno, California, 93720
United States
City of Hope Seacliff
Huntington Beach, California, 92648
United States
Keck Medicine of USC Huntington Beach
Huntington Beach, California, 92648
United States
City of Hope at Irvine Lennar
Irvine, California, 92618
United States
Kaiser Permanente-Irvine
Irvine, California, 92618
United States
City of Hope Antelope Valley
Lancaster, California, 93534
United States
Keck Medicine of USC Koreatown
Los Angeles, California, 90020
United States
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, 90027
United States
Los Angeles General Medical Center
Los Angeles, California, 90033
United States
USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033
United States
Cedars Sinai Medical Center
Los Angeles, California, 90048
United States
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, 90095
United States
Kaiser Permanente-Modesto
Modesto, California, 95356
United States
Providence Queen of The Valley
Napa, California, 94558
United States
USC Norris Oncology/Hematology-Newport Beach
Newport Beach, California, 92663
United States
Kaiser Permanente Oakland-Broadway
Oakland, California, 94611
United States
Kaiser Permanente-Oakland
Oakland, California, 94611
United States
Kaiser Permanente - Panorama City
Panorama City, California, 91402
United States
Huntington Memorial Hospital
Pasadena, California, 91105
United States
Keck Medical Center of USC Pasadena
Pasadena, California, 91105
United States
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California, 95670
United States
Kaiser Permanente- Marshall Medical Offices
Redwood City, California, 94063
United States
Kaiser Permanente-Redwood City
Redwood City, California, 94063
United States
Kaiser Permanente-Richmond
Richmond, California, 94801
United States
Kaiser Permanente-Riverside
Riverside, California, 92505
United States
Rohnert Park Cancer Center
Rohnert Park, California, 94928
United States
Kaiser Permanente-Roseville
Roseville, California, 95661
United States
The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California, 95678
United States
Kaiser Permanente Downtown Commons
Sacramento, California, 95814
United States
University of California Davis Comprehensive Cancer Center
Sacramento, California, 95817
United States
Kaiser Permanente-South Sacramento
Sacramento, California, 95823
United States
South Sacramento Cancer Center
Sacramento, California, 95823
United States
Kaiser Permanente-San Francisco
San Francisco, California, 94115
United States
UCSF Medical Center-Mission Bay
San Francisco, California, 94158
United States
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California, 95119
United States
Kaiser Permanente San Leandro
San Leandro, California, 94577
United States
Kaiser San Rafael-Gallinas
San Rafael, California, 94903
United States
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, 95051
United States
Kaiser Permanente-Santa Rosa
Santa Rosa, California, 95403
United States
Providence Medical Foundation - Santa Rosa
Santa Rosa, California, 95403
United States
Providence Santa Rosa Memorial Hospital
Santa Rosa, California, 95405
United States
City of Hope South Pasadena
South Pasadena, California, 91030
United States
Kaiser Permanente Cancer Treatment Center
South San Francisco, California, 94080
United States
Kaiser Permanente-South San Francisco
South San Francisco, California, 94080
United States
Kaiser Permanente-Stockton
Stockton, California, 95210
United States
City of Hope South Bay
Torrance, California, 90503
United States
Torrance Memorial Physician Network - Cancer Care
Torrance, California, 90505
United States
City of Hope Upland
Upland, California, 91786
United States
Kaiser Permanente Medical Center-Vacaville
Vacaville, California, 95688
United States
Kaiser Permanente-Vallejo
Vallejo, California, 94589
United States
Kaiser Permanente-Walnut Creek
Walnut Creek, California, 94596
United States
UCHealth University of Colorado Hospital
Aurora, Colorado, 80045
United States
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907
United States
UCHealth Memorial Hospital Central
Colorado Springs, Colorado, 80909
United States
Memorial Hospital North
Colorado Springs, Colorado, 80920
United States
UCHealth Highlands Ranch Hospital
Highlands Ranch, Colorado, 80129
United States
Longmont United Hospital
Longmont, Colorado, 80501
United States
Danbury Hospital
Danbury, Connecticut, 06810
United States
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut, 06830
United States
Hartford Hospital
Hartford, Connecticut, 06102
United States
The Hospital of Central Connecticut
New Britain, Connecticut, 06050
United States
Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut, 06510
United States
Yale University
New Haven, Connecticut, 06520
United States
Norwalk Hospital
Norwalk, Connecticut, 06856
United States
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut, 06385
United States
Beebe Medical Center
Lewes, Delaware, 19958
United States
Delaware Clinical and Laboratory Physicians PA
Newark, Delaware, 19713
United States
Helen F Graham Cancer Center
Newark, Delaware, 19713
United States
Medical Oncology Hematology Consultants PA
Newark, Delaware, 19713
United States
Christiana Care Health System-Christiana Hospital
Newark, Delaware, 19718
United States
Beebe Health Campus
Rehoboth Beach, Delaware, 19971
United States
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware, 19801
United States
George Washington University Medical Center
Washington, District of Columbia, 20037
United States
Florida Cancer Specialists - Bradenton Cancer Center
Bradenton, Florida, 34205
United States
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida, 33146
United States
GenesisCare USA - FGO
Fort Myers, Florida, 33905
United States
Regional Cancer Center-Lee Memorial Health System
Fort Myers, Florida, 33905
United States
University of Florida Health Science Center - Gainesville
Gainesville, Florida, 32610
United States
Jackson Memorial Hospital-Holtz Children's Hospital
Miami, Florida, 33136
United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136
United States
UM Sylvester Comprehensive Cancer Center at Kendall
Miami, Florida, 33176
United States
Sarasota Memorial Hospital-Venice
N. Venice, Florida, 34275
United States
Florida Cancer Specialists - Sarasota
Sarasota, Florida, 34232
United States
Florida Cancer Specialists - Sarasota Downtown
Sarasota, Florida, 34236
United States
First Physicians Group - Urology Robotic and Minimally Invasive Surgery
Sarasota, Florida, 34239
United States
First Physicians Group-Sarasota
Sarasota, Florida, 34239
United States
Sarasota Memorial Hospital
Sarasota, Florida, 34239
United States
Sarasota Memorial Health Care Center at University Parkway
Sarasota, Florida, 34243
United States
Florida Cancer Specialists - Venice Island
Venice, Florida, 34285
United States
Florida Cancer Specialists - Venice Healthpark
Venice, Florida, 34292
United States
Grady Health System
Atlanta, Georgia, 30303
United States
Emory University Hospital Midtown
Atlanta, Georgia, 30308
United States
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia, 30322
United States
Emory Saint Joseph's Hospital
Atlanta, Georgia, 30342
United States
Northside Hospital
Atlanta, Georgia, 30342
United States
Augusta University Medical Center
Augusta, Georgia, 30912
United States
CTCA at Southeastern Regional Medical Center
Newnan, Georgia, 30265
United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia, 31405
United States
Hawaii Cancer Care - Westridge
'Aiea, Hawaii, 96701
United States
Pali Momi Medical Center
'Aiea, Hawaii, 96701
United States
Queen's Cancer Center - Pearlridge
'Aiea, Hawaii, 96701
United States
The Cancer Center of Hawaii-Pali Momi
'Aiea, Hawaii, 96701
United States
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii, 96813
United States
Island Urology
Honolulu, Hawaii, 96813
United States
Queen's Cancer Cenrer - POB I
Honolulu, Hawaii, 96813
United States
Queen's Medical Center
Honolulu, Hawaii, 96813
United States
Straub Clinic and Hospital
Honolulu, Hawaii, 96813
United States
University of Hawaii Cancer Center
Honolulu, Hawaii, 96813
United States
Hawaii Cancer Care Inc-Liliha
Honolulu, Hawaii, 96817
United States
Kuakini Medical Center
Honolulu, Hawaii, 96817
United States
Queen's Cancer Center - Kuakini
Honolulu, Hawaii, 96817
United States
The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii, 96817
United States
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii, 96819
United States
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, 96826
United States
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue, Hawaii, 96766
United States
Saint Luke's Cancer Institute - Boise
Boise, Idaho, 83712
United States
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho, 83619
United States
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho, 83642
United States
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho, 83686
United States
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho, 83301
United States
Rush - Copley Medical Center
Aurora, Illinois, 60504
United States
Advocate Good Shepherd Hospital
Barrington, Illinois, 60010
United States
Bromenn Lifecare Center
Bloomington, Illinois, 61701
United States
Northwestern University
Chicago, Illinois, 60611
United States
Rush University Medical Center
Chicago, Illinois, 60612
United States
University of Illinois
Chicago, Illinois, 60612
United States
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637
United States
Advocate Illinois Masonic Medical Center
Chicago, Illinois, 60657
United States
AMG Crystal Lake - Oncology
Crystal Lake, Illinois, 60014
United States
Carle at The Riverfront
Danville, Illinois, 61832
United States
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, 60115
United States
Advocate Good Samaritan Hospital
Downers Grove, Illinois, 60515
United States
Carle Physician Group-Effingham
Effingham, Illinois, 62401
United States
Advocate Sherman Hospital
Elgin, Illinois, 60123
United States
Elmhurst Memorial Hospital
Elmhurst, Illinois, 60126
United States
NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois, 60201
United States
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, 60134
United States
NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois, 60026
United States
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois, 60026
United States
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois, 60030
United States
Advocate South Suburban Hospital
Hazel Crest, Illinois, 60429
United States
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois, 60035
United States
Sudarshan K Sharma MD Limited-Gynecologic Oncology
Hinsdale, Illinois, 60521
United States
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, 60045
United States
AMG Libertyville - Oncology
Libertyville, Illinois, 60048
United States
Condell Memorial Hospital
Libertyville, Illinois, 60048
United States
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois, 61938
United States
Edward Hospital/Cancer Center
Naperville, Illinois, 60540
United States
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois, 60451
United States
Bromenn Regional Medical Center
Normal, Illinois, 61761
United States
Carle Cancer Institute Normal
Normal, Illinois, 61761
United States
Advocate Christ Medical Center
Oak Lawn, Illinois, 60453-2699
United States
University of Chicago Medicine-Orland Park
Orland Park, Illinois, 60462
United States
Advocate Lutheran General Hospital
Park Ridge, Illinois, 60068
United States
Edward Hospital/Cancer Center?Plainfield
Plainfield, Illinois, 60585
United States
Memorial Medical Center
Springfield, Illinois, 62781
United States
Carle Cancer Center
Urbana, Illinois, 61801
United States
The Carle Foundation Hospital
Urbana, Illinois, 61801
United States
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, 60555
United States
Rush-Copley Healthcare Center
Yorkville, Illinois, 60560
United States
Midwestern Regional Medical Center
Zion, Illinois, 60099
United States
IU Health North Hospital
Carmel, Indiana, 46032
United States
Goshen Center for Cancer Care
Goshen, Indiana, 46526
United States
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202
United States
Community Cancer Center North
Indianapolis, Indiana, 46256
United States
Baptist Health Floyd
New Albany, Indiana, 47150
United States
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242
United States
University of Kansas Clinical Research Center
Fairway, Kansas, 66205
United States
University of Kansas Cancer Center
Kansas City, Kansas, 66160
United States
University of Kansas Hospital-Indian Creek Campus
Overland Park, Kansas, 66211
United States
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas, 66205
United States
Baptist Health Corbin
Corbin, Kentucky, 40701
United States
Saint Elizabeth Healthcare Edgewood
Edgewood, Kentucky, 41017
United States
Baptist Health Hardin
Elizabethtown, Kentucky, 42701
United States
Baptist Health Lexington
Lexington, Kentucky, 40503
United States
Baptist Health Louisville
Louisville, Kentucky, 40207
United States
Norton Suburban Hospital and Medical Campus
Louisville, Kentucky, 40207
United States
Baptist Health Madisonville/Merle Mahr Cancer Center
Madisonville, Kentucky, 42431
United States
Baptist Health Paducah
Paducah, Kentucky, 42003
United States
Baptist Health Richmond
Richmond, Kentucky, 40475
United States
West Jefferson Medical Center
Marrero, Louisiana, 70072
United States
Louisiana State University Health Science Center
New Orleans, Louisiana, 70112
United States
University Medical Center New Orleans
New Orleans, Louisiana, 70112
United States
Willis-Knighton Medical and Cancer Center
Shreveport, Louisiana, 71103
United States
Maine Medical Center-Bramhall Campus
Portland, Maine, 04102
United States
Maine Medical Center- Scarborough Campus
Scarborough, Maine, 04074
United States
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, 21201
United States
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287
United States
Walter Reed National Military Medical Center
Bethesda, Maryland, 20889-5600
United States
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie, Maryland, 21061
United States
Baystate Medical Center
Springfield, Massachusetts, 01199
United States
Corewell Health Dearborn Hospital
Dearborn, Michigan, 48124
United States
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, 48201
United States
Weisberg Cancer Treatment Center
Farmington Hills, Michigan, 48334
United States
Corewell Health Farmington Hills Hospital
Farmington Hills, Michigan, 48336
United States
McLaren Cancer Institute-Flint
Flint, Michigan, 48532
United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan, 49503
United States
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007
United States
West Michigan Cancer Center
Kalamazoo, Michigan, 49007
United States
Borgess Medical Center
Kalamazoo, Michigan, 49048
United States
Trinity Health Muskegon Hospital
Muskegon, Michigan, 49444
United States
Oakland Colon Rectal Associates
Royal Oak, Michigan, 48067
United States
Cancer Care Associates PC
Royal Oak, Michigan, 48073
United States
Comprehensive Medical Center PLLC
Royal Oak, Michigan, 48073
United States
Corewell Health William Beaumont University Hospital
Royal Oak, Michigan, 48073
United States
Hematology Oncology Consultants PC
Royal Oak, Michigan, 48073
United States
Oakland Medical Group
Royal Oak, Michigan, 48073
United States
Premier Hematology Oncology Care
Sterling Heights, Michigan, 48312
United States
Michigan Institute of Urology-Town Center
Troy, Michigan, 48084
United States
Corewell Health Beaumont Troy Hospital
Troy, Michigan, 48085
United States
Hematology Oncology Consultants PC-Troy
Troy, Michigan, 48098
United States
Minnesota Oncology - Burnsville
Burnsville, Minnesota, 55337
United States
Cambridge Medical Center
Cambridge, Minnesota, 55008
United States
Mercy Hospital
Coon Rapids, Minnesota, 55433
United States
Fairview Southdale Hospital
Edina, Minnesota, 55435
United States
Unity Hospital
Fridley, Minnesota, 55432
United States
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota, 55369
United States
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109
United States
Saint John's Hospital - Healtheast
Maplewood, Minnesota, 55109
United States
Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407
United States
Hennepin County Medical Center
Minneapolis, Minnesota, 55415
United States
Health Partners Inc
Minneapolis, Minnesota, 55454
United States
University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota, 55455
United States
Monticello Cancer Center
Monticello, Minnesota, 55362
United States
New Ulm Medical Center
New Ulm, Minnesota, 56073
United States
Fairview Northland Medical Center
Princeton, Minnesota, 55371
United States
North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422
United States
Mayo Clinic in Rochester
Rochester, Minnesota, 55905
United States
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416
United States
Regions Hospital
Saint Paul, Minnesota, 55101
United States
United Hospital
Saint Paul, Minnesota, 55102
United States
Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379
United States
Lakeview Hospital
Stillwater, Minnesota, 55082
United States
Ridgeview Medical Center
Waconia, Minnesota, 55387
United States
Rice Memorial Hospital
Willmar, Minnesota, 56201
United States
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, 55125
United States
Fairview Lakes Medical Center
Wyoming, Minnesota, 55092
United States
University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City, Missouri, 64116
United States
Washington University School of Medicine
Saint Louis, Missouri, 63110
United States
Mercy Hospital South
Saint Louis, Missouri, 63128
United States
Missouri Baptist Medical Center
Saint Louis, Missouri, 63131
United States
Mercy Hospital Saint Louis
Saint Louis, Missouri, 63141
United States
Mercy Hospital Springfield
Springfield, Missouri, 65804
United States
CoxHealth South Hospital
Springfield, Missouri, 65807
United States
Billings Clinic Cancer Center
Billings, Montana, 59101
United States
Bozeman Health Deaconess Hospital
Bozeman, Montana, 59715
United States
Saint Patrick Hospital - Community Hospital
Missoula, Montana, 59802
United States
Community Medical Center
Missoula, Montana, 59804
United States
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
Omaha, Nebraska, 68114
United States
Nebraska Methodist Hospital
Omaha, Nebraska, 68114
United States
Oncology Associates PC
Omaha, Nebraska, 68114
United States
Nebraska Medicine-Village Pointe
Omaha, Nebraska, 68118
United States
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska, 68124
United States
University of Nebraska Medical Center
Omaha, Nebraska, 68198
United States
Women's Cancer Center of Nevada
Las Vegas, Nevada, 89106
United States
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, 07920
United States
Cooper Hospital University Medical Center
Camden, New Jersey, 08103
United States
Jersey City Medical Center
Jersey City, New Jersey, 07302
United States
Saint Barnabas Medical Center
Livingston, New Jersey, 07039
United States
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, 07748
United States
Memorial Sloan Kettering Bergen
Montvale, New Jersey, 07645
United States
Morristown Medical Center
Morristown, New Jersey, 07960
United States
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903
United States
Rutgers New Jersey Medical School
Newark, New Jersey, 07101
United States
Capital Health Medical Center-Hopewell
Pennington, New Jersey, 08534
United States
Penn Medicine Princeton Health
Plainsboro, New Jersey, 08536
United States
Robert Wood Johnson University Hospital Somerset
Somerville, New Jersey, 08876
United States
Overlook Hospital
Summit, New Jersey, 07902
United States
University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106
United States
Presbyterian Kaseman Hospital
Albuquerque, New Mexico, 87110
United States
Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho, New Mexico, 87124
United States
Women's Cancer Care Associates LLC
Albany, New York, 12208
United States
Northwell Health Imbert Cancer Center
Bay Shore, New York, 11706
United States
South Shore University Hospital
Bay Shore, New York, 11706
United States
Island Gynecologic Oncology
Brightwaters, New York, 11718
United States
Memorial Sloan Kettering Commack
Commack, New York, 11725
United States
Memorial Sloan Kettering Westchester
Harrison, New York, 10604
United States
Huntington Hospital
Huntington, New York, 11743
United States
Northwell Health/Center for Advanced Medicine
Lake Success, New York, 11042
United States
North Shore University Hospital
Manhasset, New York, 11030
United States
NYU Langone Hospital - Long Island
Mineola, New York, 11501
United States
Northern Westchester Hospital
Mount Kisco, New York, 10549
United States
Long Island Jewish Medical Center
New Hyde Park, New York, 11040
United States
Northwell Health Physician Partners
New Hyde Park, New York, 11042
United States
Mount Sinai Chelsea
New York, New York, 10011
United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York, 10016
United States
Mount Sinai West
New York, New York, 10019
United States
Lenox Hill Hospital
New York, New York, 10021
United States
Mount Sinai Hospital
New York, New York, 10029
United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032
United States
Memorial Sloan Kettering Cancer Center
New York, New York, 10065
United States
NYP/Weill Cornell Medical Center
New York, New York, 10065
United States
Vassar Brothers Medical Center
Poughkeepsie, New York, 12601
United States
Northwell Physician Partners at Rego Park
Rego Park, New York, 11374
United States
Queens Cancer Center
Rego Park, New York, 11374
United States
Highland Hospital
Rochester, New York, 14620
United States
University of Rochester
Rochester, New York, 14642
United States
Phelps Memorial Hospital Center
Sleepy Hollow, New York, 10591
United States
Stony Brook University Medical Center
Stony Brook, New York, 11794
United States
State University of New York Upstate Medical University
Syracuse, New York, 13210
United States
Memorial Sloan Kettering Nassau
Uniondale, New York, 11553
United States
Duke Cancer Institute Cary
Cary, North Carolina, 27518
United States
Duke University Medical Center
Durham, North Carolina, 27710
United States
Duke Women's Cancer Care Raleigh
Raleigh, North Carolina, 27607
United States
Duke Raleigh Hospital
Raleigh, North Carolina, 27609
United States
Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157
United States
Aultman Alliance Community Hospital
Alliance, Ohio, 44601
United States
Aultman Health Foundation
Canton, Ohio, 44710
United States
Miami Valley Hospital South
Centerville, Ohio, 45459
United States
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio, 45219
United States
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio, 45220
United States
Bethesda North Hospital
Cincinnati, Ohio, 45242
United States
TriHealth Cancer Institute-Westside
Cincinnati, Ohio, 45247
United States
TriHealth Cancer Institute-Anderson
Cincinnati, Ohio, 45255
United States
MetroHealth Medical Center
Cleveland, Ohio, 44109
United States
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio, 44111
United States
Cleveland Clinic Foundation
Cleveland, Ohio, 44195
United States
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210
United States
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio, 43214
United States
Riverside Methodist Hospital
Columbus, Ohio, 43214
United States
Grant Medical Center
Columbus, Ohio, 43215
United States
Doctors Hospital
Columbus, Ohio, 43228
United States
Miami Valley Hospital
Dayton, Ohio, 45409
United States
Miami Valley Hospital North
Dayton, Ohio, 45415
United States
Delaware Health Center-Grady Cancer Center
Delaware, Ohio, 43015
United States
Grady Memorial Hospital
Delaware, Ohio, 43015
United States
Columbus Oncology and Hematology Associates
Dublin, Ohio, 43016
United States
Dublin Methodist Hospital
Dublin, Ohio, 43016
United States
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio, 45005-1066
United States
Miami Valley Cancer Care and Infusion
Greenville, Ohio, 45331
United States
OhioHealth Mansfield Hospital
Mansfield, Ohio, 44903
United States
OhioHealth Marion General Hospital
Marion, Ohio, 43302
United States
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio, 44124
United States
ProMedica Flower Hospital
Sylvania, Ohio, 43560
United States
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo, Ohio, 43606
United States
Upper Valley Medical Center
Troy, Ohio, 45373
United States
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio, 45069
United States
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104
United States
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma, 73120
United States
Saint Charles Health System
Bend, Oregon, 97701
United States
Clackamas Radiation Oncology Center
Clackamas, Oregon, 97015
United States
Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon, 97015
United States
Bay Area Hospital
Coos Bay, Oregon, 97420
United States
Providence Newberg Medical Center
Newberg, Oregon, 97132
United States
Providence Willamette Falls Medical Center
Oregon City, Oregon, 97045
United States
Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon, 97210
United States
Providence Portland Medical Center
Portland, Oregon, 97213
United States
Providence Saint Vincent Medical Center
Portland, Oregon, 97225
United States
Oregon Health and Science University
Portland, Oregon, 97239
United States
Saint Charles Health System-Redmond
Redmond, Oregon, 97756
United States
Legacy Meridian Park Hospital
Tualatin, Oregon, 97062
United States
Jefferson Abington Hospital
Abington, Pennsylvania, 19001
United States
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania, 19317
United States
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania, 17033-0850
United States
Jefferson Hospital
Jefferson Hills, Pennsylvania, 15025
United States
Lancaster General Ann B Barshinger Cancer Institute
Lancaster, Pennsylvania, 17601
United States
Lancaster General Hospital
Lancaster, Pennsylvania, 17602
United States
Forbes Hospital
Monroeville, Pennsylvania, 15146
United States
Allegheny Valley Hospital
Natrona Heights, Pennsylvania, 15065
United States
University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania, 19104
United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107
United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111
United States
Allegheny General Hospital
Pittsburgh, Pennsylvania, 15212
United States
West Penn Hospital
Pittsburgh, Pennsylvania, 15224
United States
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania, 15232
United States
Chester County Hospital
West Chester, Pennsylvania, 19380
United States
Wexford Health and Wellness Pavilion
Wexford, Pennsylvania, 15090
United States
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania, 19090
United States
Women and Infants Hospital
Providence, Rhode Island, 02905
United States
Saint Joseph's/Candler - Bluffton Campus
Bluffton, South Carolina, 29910
United States
Gibbs Cancer Center-Gaffney
Gaffney, South Carolina, 29341
United States
Prisma Health Cancer Institute - Faris
Greenville, South Carolina, 29605
United States
Prisma Health Greenville Memorial Hospital
Greenville, South Carolina, 29605
United States
Gibbs Cancer Center-Pelham
Greer, South Carolina, 29651
United States
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina, 29672
United States
Spartanburg Medical Center
Spartanburg, South Carolina, 29303
United States
MGC Hematology Oncology-Union
Union, South Carolina, 29379
United States
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota, 57104
United States
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134
United States
Vanderbilt-Ingram Cancer Center at Franklin
Franklin, Tennessee, 37067
United States
Vanderbilt-Ingram Cancer Center Cool Springs
Franklin, Tennessee, 37067
United States
Vanderbilt Breast Center at One Hundred Oaks
Nashville, Tennessee, 37204
United States
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee, 37232
United States
Parkland Memorial Hospital
Dallas, Texas, 75235
United States
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390
United States
Brooke Army Medical Center
Fort Sam Houston, Texas, 78234
United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas, 77030
United States
Ben Taub General Hospital
Houston, Texas, 77030
United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229
United States
University of Utah Sugarhouse Health Center
Salt Lake City, Utah, 84106
United States
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112
United States
University of Virginia Cancer Center
Charlottesville, Virginia, 22908
United States
Inova Schar Cancer Institute
Fairfax, Virginia, 22031
United States
Inova Fair Oaks Hospital
Fairfax, Virginia, 22033
United States
Inova Fairfax Hospital
Falls Church, Virginia, 22042
United States
Henrico Doctor's Hospital
Richmond, Virginia, 23229
United States
VCU Massey Cancer Center at Stony Point
Richmond, Virginia, 23235
United States
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia, 23298
United States
Carilion Clinic Gynecological Oncology
Roanoke, Virginia, 24016
United States
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington, 98520
United States
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington, 98225
United States
Providence Regional Cancer System-Centralia
Centralia, Washington, 98531
United States
Swedish Cancer Institute-Edmonds
Edmonds, Washington, 98026
United States
Providence Regional Cancer Partnership
Everett, Washington, 98201
United States
Swedish Cancer Institute-Issaquah
Issaquah, Washington, 98029
United States
Kadlec Clinic Hematology and Oncology
Kennewick, Washington, 99336
United States
Providence Regional Cancer System-Lacey
Lacey, Washington, 98503
United States
PeaceHealth Saint John Medical Center
Longview, Washington, 98632
United States
Skagit Regional Health Cancer Care Center
Mount Vernon, Washington, 98274
United States
Swedish Medical Center-Ballard Campus
Seattle, Washington, 98107
United States
FHCC South Lake Union
Seattle, Washington, 98109
United States
Fred Hutchinson Cancer Center
Seattle, Washington, 98109
United States
Swedish Medical Center-Cherry Hill
Seattle, Washington, 98122-5711
United States
Swedish Medical Center-First Hill
Seattle, Washington, 98122
United States
University of Washington Medical Center - Northwest
Seattle, Washington, 98133
United States
Women's Cancer Center of Seattle
Seattle, Washington, 98133
United States
University of Washington Medical Center - Montlake
Seattle, Washington, 98195
United States
PeaceHealth United General Medical Center
Sedro-Woolley, Washington, 98284
United States
Providence Regional Cancer System-Shelton
Shelton, Washington, 98584
United States
Legacy Salmon Creek Hospital
Vancouver, Washington, 98686
United States
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington, 99362
United States
Providence Regional Cancer System-Yelm
Yelm, Washington, 98597
United States
United Hospital Center
Bridgeport, West Virginia, 26330
United States
West Virginia University Charleston Division
Charleston, West Virginia, 25304
United States
WVUH-Berkely Medical Center
Martinsburg, West Virginia, 25401
United States
West Virginia University Healthcare
Morgantown, West Virginia, 26506
United States
Camden Clark Medical Center
Parkersburg, West Virginia, 26101
United States
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin, 53105
United States
Aurora Saint Luke's South Shore
Cudahy, Wisconsin, 53110
United States
Aurora Health Care Germantown Health Center
Germantown, Wisconsin, 53022
United States
Aurora Cancer Care-Grafton
Grafton, Wisconsin, 53024
United States
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin, 54301
United States
Aurora BayCare Medical Center
Green Bay, Wisconsin, 54311
United States
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin, 53142
United States
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792
United States
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin, 54143
United States
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin, 54449
United States
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin, 53209
United States
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, 53215
United States
Medical College of Wisconsin
Milwaukee, Wisconsin, 53226
United States
Aurora Sinai Medical Center
Milwaukee, Wisconsin, 53233
United States
ProHealth D N Greenwald Center
Mukwonago, Wisconsin, 53149
United States
Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017
United States
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin, 53066
United States
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin, 54904
United States
Aurora Cancer Care-Racine
Racine, Wisconsin, 53406
United States
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin, 53081
United States
Aurora Medical Center in Summit
Summit, Wisconsin, 53066
United States
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin, 54241
United States
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin, 53188
United States
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin, 53188
United States
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin, 53226
United States
Aurora West Allis Medical Center
West Allis, Wisconsin, 53227
United States

Collaborators and Investigators

Sponsor: NRG Oncology

  • Kathryn P Pennington, PRINCIPAL_INVESTIGATOR, NRG Oncology

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-09-01
Study Completion Date2037-06-23

Study Record Updates

Study Start Date2020-09-01
Study Completion Date2037-06-23

Terms related to this study

Additional Relevant MeSH Terms

  • Ovarian Carcinoma