Impact of Estradiol on Endothelial Function in Peri-Menopausal Women

Description

The purpose of this study is to identify the impact of estradiol (E2) on the mechanisms that regulate vascular endothelial function in peri-menopausal (PERI) women. This study is the first step in understanding factors contributing to endothelial dysfunction in women with advancing reproductive age and in response to E2 administration.

Conditions

Perimenopause, Vasodilation, Estrogen

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Study Overview

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Study Details

Study overview

The purpose of this study is to identify the impact of estradiol (E2) on the mechanisms that regulate vascular endothelial function in peri-menopausal (PERI) women. This study is the first step in understanding factors contributing to endothelial dysfunction in women with advancing reproductive age and in response to E2 administration.

Impact of Estradiol on Endothelial Function in Peri-Menopausal Women

Impact of Estradiol on Endothelial Function in Peri-Menopausal Women

Condition
Perimenopause
Intervention / Treatment

-

Contacts and Locations

Newark

University of Delaware, Newark, Delaware, United States, 19716

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Peri-menopausal women between 40-58 years of age with variable cycles as defined by increase in cycle length of greater than 7 days within ten consecutive cycles, or amenorrhea for more than 2 months, but less than 12 months.
  • * Women who are pregnant, planning on becoming pregnant, or are breast feeding;
  • * Women who have a history of cardiovascular disease, blood clots (e.g, pulmonary embolism or deep vein thrombosis), stroke, cancer, or liver disease;
  • * Women who have a body mass index less than 18 or greater than 35kg/m2;
  • * Women who use tobacco products;
  • * Women who's blood pressure is greater than 140/90 mmHg, have been diagnosed by a physician with hypertension or are taking medication for high blood pressure;
  • * Women who have a neurological disease, or diabetes;
  • * Women who have had a hysterectomy or have used hormones (birth control or hormone replacement) within the past 3 months;
  • * Women who have a latex allergy.

Ages Eligible for Study

40 Years to 58 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Delaware,

Study Record Dates

2025-09-30