Genome Environment Microbiome and Metabolome in Autism Study

Description

GEMMA is a multicenter longitudinal observational study that follows children who are genetically at-risk of developing autism for their first three years of life, seeking to identify potential biomarkers predictive of autism development in the blood, stool, urine and saliva. The biomarkers identified in this project will contribute to a better understanding of the pathogenesis of ASD in at-risk children and possible solutions for alleviating and/or preventing ASD and ASD-related symptoms in patients in the future.

Conditions

Autism Spectrum Disorder

Study Overview

Study Details

Study overview

GEMMA is a multicenter longitudinal observational study that follows children who are genetically at-risk of developing autism for their first three years of life, seeking to identify potential biomarkers predictive of autism development in the blood, stool, urine and saliva. The biomarkers identified in this project will contribute to a better understanding of the pathogenesis of ASD in at-risk children and possible solutions for alleviating and/or preventing ASD and ASD-related symptoms in patients in the future.

Genome Environment Microbiome and Metabolome in Autism

Genome Environment Microbiome and Metabolome in Autism Study

Condition
Autism Spectrum Disorder
Intervention / Treatment

-

Contacts and Locations

Boston

Massachusetts General Hospital for Children, Boston, Massachusetts, United States, 02114

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy newborns and infants less than 6 months of age who have not been introduced to solid foods (elementary formula feeding is permitted)
  • * First-degree relatives of ASD individuals (at least one sibling affected by ASD)
  • * Infants older than 6 months of age
  • * Inability or unwillingness of legal guardian/representative to give written informed consent

Ages Eligible for Study

to 6 Months

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Massachusetts General Hospital,

Alessio Fasano, MD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

2025-12-31