COMPLETED

Physiological Changes Induced Through MEP Conditioning in People With SCI

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The study team is currently recruiting volunteers who are interested in participating in a brain-spinal cord-muscle response training study that aims to better understand the changes that take place in the nervous system as a result of this type of training. After spinal cord injury, brain-to-muscle connections are often interrupted. Because these connections are important in movement control, when they are not working well, movements may be disturbed. Researchers have found that people can learn to strengthen these connections through training. Strengthening these connections may be able to improve movement control and recovery after injuries. Research participants will be asked to stand, sit, and walk during the study sessions. Electrodes are placed on the skin over leg muscles for monitoring muscle activity. For examining brain-to-muscle connections, the study team will use transcranial magnetic stimulation. The stimulation is applied over the head and will indirectly stimulate brain cells with little or no discomfort. Participation in this study requires approximately three sessions per week for four months, followed by two to three sessions over another three months. Each session lasts approximately 1 hour.

Official Title

Characterization of Physiological Changes Induced Through Motor-evoked Potential Conditioning in People With Spinal Cord Injury

Quick Facts

Study Start:2021-02-22
Study Completion:2025-11-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT04286191

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Neurologically stable (\>1 year post SCI)
  2. * Medical clearance to participate
  3. * Ability to ambulate at least 10 m with or without an assistive device (except for parallel bars)
  4. * Signs of weak ankle dorsiflexion at least unilaterally
  5. * Expectation that current medication will be maintained without change for at least 3 months; stable use of anti-spasticity medication is accepted
  1. * motoneuron injury
  2. * known cardiac condition (e.g., history of myocardial infarction, congestive heart failure, pacemaker use)
  3. * medically unstable condition
  4. * cognitive impairment
  5. * history of epileptic seizures
  6. * metal implants in the cranium
  7. * implanted biomedical device in or above the ches (e.g., a cardiac pacemaker, cochlear implant)
  8. * no measurable MEP elicited
  9. * unable to produce any voluntary TA EMG activity
  10. * extensive use of functional electrical stimulation to the leg on a daily basis
  11. * pregnancy (due to changes in weight and posture and potential medical instability)

Contacts and Locations

Principal Investigator

Aiko K Thompson, PhD
PRINCIPAL_INVESTIGATOR
Medical University of South Carolina

Study Locations (Sites)

Medical University of South Carolina
Charleston, South Carolina, 29425
United States

Collaborators and Investigators

Sponsor: Medical University of South Carolina

  • Aiko K Thompson, PhD, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-02-22
Study Completion Date2025-11-30

Study Record Updates

Study Start Date2021-02-22
Study Completion Date2025-11-30

Terms related to this study

Keywords Provided by Researchers

  • Corticospinal Tract
  • Neuroplasticity

Additional Relevant MeSH Terms

  • Spinal Cord Injuries
  • Neurological Injury
  • Paralysis
  • Spasticity, Muscle