Preeclampsia Postpartum Antihypertensive Treatment

Description

The goal of this study is to compare whether antihypertensive treatment in the postpartum period decreases postpartum hypertension and its associated maternal morbidity, including risk of readmission and healthcare utilization in comparison with no treatment. Women with preeclampsia diagnosed during the antepartum, intrapartum or postpartum period will be randomized to either initiate antihypertensive treatment or standard of care. We hypothesize that postpartum antihypertensive treatment of patients with preeclampsia will decrease risk of hospital readmission, healthcare utilization and the number of severe range blood pressures at postpartum follow-up visits.

Conditions

Preeclampsia, Hypertension in Pregnancy

Study Overview

Study Details

Study overview

The goal of this study is to compare whether antihypertensive treatment in the postpartum period decreases postpartum hypertension and its associated maternal morbidity, including risk of readmission and healthcare utilization in comparison with no treatment. Women with preeclampsia diagnosed during the antepartum, intrapartum or postpartum period will be randomized to either initiate antihypertensive treatment or standard of care. We hypothesize that postpartum antihypertensive treatment of patients with preeclampsia will decrease risk of hospital readmission, healthcare utilization and the number of severe range blood pressures at postpartum follow-up visits.

Randomized Controlled Trial for Postpartum Antihypertensive Treatment of Women With Preeclampsia

Preeclampsia Postpartum Antihypertensive Treatment

Condition
Preeclampsia
Intervention / Treatment

-

Contacts and Locations

Milwaukee

Medical College of Wisconsin-Froedtert Hospital, Milwaukee, Wisconsin, United States, 53226

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age \>= 18 years old
  • * Immediately postpartum (delivered in previous 96 hours)
  • * Diagnosed with preeclampsia during pregnancy, labor or immediately postpartum
  • * \>30% of blood pressures in the postpartum period were elevated (systolic 140 or higher OR diastolic 90 or higher)
  • * Chronic hypertension with superimposed preeclampsia
  • * Diagnosis of preeclampsia after discharge from delivery hospitalization
  • * Persistent severe range blood pressures after delivery requiring initiation of antihypertensive regimen by the care team
  • * \>50% of blood pressures in the postpartum period were normal (systolic less than 140 AND diastolic less than 90)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Medical College of Wisconsin,

Study Record Dates

2025-06-30