The purpose of this research study is to evaluate if special types of cells called round spermatids can be gathered from men with non-obstructive azoospermia and used (in absence of elongated spermatids and spermatozoa) to reliably and effectively create pregnancy with a procedure called Round Spermatid Injection (ROSI). This process is similar to In Vitro Fertilization, or 'IVF'. In addition, this study wants to test the safety of ROSI and see what effects (good and bad) it has on embryo created from this method.
Infertility, Male
The purpose of this research study is to evaluate if special types of cells called round spermatids can be gathered from men with non-obstructive azoospermia and used (in absence of elongated spermatids and spermatozoa) to reliably and effectively create pregnancy with a procedure called Round Spermatid Injection (ROSI). This process is similar to In Vitro Fertilization, or 'IVF'. In addition, this study wants to test the safety of ROSI and see what effects (good and bad) it has on embryo created from this method.
Experimental Round Spermatid Injection (ROSI) to Treat Infertile Couples
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Carolinas Fertility Institute (CFI), Winston-Salem, North Carolina, United States, 27103
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
18 Years to
MALE
No
Wake Forest University Health Sciences,
Hooman Sadri, MD, PhD, PRINCIPAL_INVESTIGATOR, Wake Forest Institute for Regenerative Medicine (WFIRM)
Hooman Sadri, MD, PhD, STUDY_DIRECTOR, Wake Forest University Health Sciences
2024-12