The Impact of Insomnia on Pain in HIV

Description

The overall objective of this application is to investigate the impact of insomnia on pain, physical functioning, and inflammation in people living with HIV. The two aims of this study to determine 1) whether insomnia promotes increased sensitivity and inflammatory reactivity to pain stimuli, and 2) if weekly fluctuations in insomnia burden drive changes in inflammation, pain severity, and physical functioning in people living with HIV. This research could help confirm insomnia as a therapeutic target for the suppression of pain and inflammation in people living with HIV.

Conditions

HIV, Insomnia

Talk to us

Study Overview

On this page

Study Details

Study overview

The overall objective of this application is to investigate the impact of insomnia on pain, physical functioning, and inflammation in people living with HIV. The two aims of this study to determine 1) whether insomnia promotes increased sensitivity and inflammatory reactivity to pain stimuli, and 2) if weekly fluctuations in insomnia burden drive changes in inflammation, pain severity, and physical functioning in people living with HIV. This research could help confirm insomnia as a therapeutic target for the suppression of pain and inflammation in people living with HIV.

The Impact of Insomnia on Pain, Physical Function, and Inflammation in HIV

The Impact of Insomnia on Pain in HIV

Condition
HIV
Intervention / Treatment

-

Contacts and Locations

Birmingham

UAB, Birmingham, Alabama, United States, 35294

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Confirmed HIV diagnosis
  • * currently a patient in the University of Alabama (UAB) 1917 HIV Clinic.
  • * must be currently receiving stable antiretroviral therapy (ART).
  • * Meets the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) diagnostic criteria for insomnia including sleep difficulty.
  • * Confirmed HIV diagnosis
  • * currently a patient in the University of Alabama (UAB) 1917 HIV Clinic.
  • * must be currently receiving stable antiretroviral therapy (ART).
  • * Does not meet the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) diagnostic criteria for insomnia including sleep difficulty.
  • * Confirmed Non HIV diagnosis and currently not a patient in the UAB 1917 HIV Clinic.
  • * Meets DSM-5 diagnostic criteria for insomnia including sleep difficulty.
  • * Confirmed Non HIV diagnosis and currently not a patient in the UAB 1917 HIV Clinic.
  • * Does not meets DSM-5 diagnostic criteria for insomnia including sleep difficulty.
  • * concurrent medical conditions that could confound
  • * interpretation of sleep
  • * pain
  • * inflammatory issues or coexisting diseases
  • * Systemic rheumatic disease/condition
  • * uncontrolled hypertension (i.e., BP \> 150/95)
  • * circulatory disorders (e.g., Reynaud's disease)
  • * history of heart disease or cardiac events
  • * history of cancer
  • * asthma AND use of an inhaler
  • * history of seizures
  • * history of stroke or other neurological disorder
  • * pregnancy
  • * core body temperature \> 100 degrees Fahrenheit as this could indicate acute infection with fever; (k)
  • * unwilling to provide blood for this study
  • * non-English speaking
  • * recent injury or surgical procedure within past 6 months.

Ages Eligible for Study

18 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Alabama at Birmingham,

Burel R Goodin, PHd, PRINCIPAL_INVESTIGATOR, University of Alabama at Birmingham

Study Record Dates

2025-07-31