RECRUITING

NHS-IL12 Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma

Conditions

Kaposi Sarcoma Immune Therapy AIDS HIV Immunocytokine

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Background: Kaposi sarcoma (KS) tumors grow on the skin, lymph nodes, lungs, bone, and gastrointestinal tract. KS often affects people with immune deficiencies, such as among people living with HIV or those with prior history of transplant. Researchers want to see if 2 non-chemotherapy drugs can help people with KS. NHS-IL12 triggers the immune system to fight tumors. M7824 blocks the pathways that cancer cells use to stop the immune system from fighting tumors. Objective: To learn if giving NHS-IL12 alone or with M7824 could help the immune system fight KS tumors. Eligibility: People 18 and older with KS that has been treated with chemotherapy or immunotherapy Design: Participants will be screened with some or all of the following: medical history physical exam chest X-ray computed tomography scan blood and urine tests electrocardiogram and echocardiogram skin KS lesion biopsy lung exam gastrointestinal exam All participants will get NHS-IL12 every 4 weeks for up to 96 weeks (or 24cycles). It is injected under the skin. Some participants will also get M7824 every 2 weeks for up to 96 weeks (or 24cycles). It is given through a plastic tube that is put in an arm vein. Participants will complete questionnaires about how KS affects their quality of life. Their KS lesions will be measured and photographed. They will repeat some of the screening tests. They will give saliva samples or additional tissue samples. They will have a lung function test. Their ability to perform their normal activities will be assessed. The treatment duration is up to 96 weeks (or 24cycles) with an option to take NHS-IL12 and/or M7824 until the KS tumors are not responding, or you develop unacceptable side effects. Participants will have follow-up visits 7 and 30 days after treatment ends, then every 3 to 6 months for the next 18 months, then once a year for 3 years.

Official Title

Phase I/II Study of PDS01ADC Monotherapy and in Combination With M7824 in Advanced Kaposi Sarcoma

Quick Facts

Study Start:2020-07-13

Study Completion:2028-12-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT04303117

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Individuals with biopsy proven (confirmed in the Laboratory of Pathology, CCR) Kaposi sarcoma (KS) * KS requiring systemic therapy, with or without history of prior KS therapy: * T1 KS or T0 KS sufficiently widespread that systemic therapy is advisable, or KS affecting quality-of-life due to local symptoms or psychological distress * KS with an inadequate response to liposomal doxorubicin, paclitaxel, other systemic chemotherapy (either progressive disease or stable disease after 3 or more cycles) or immunotherapy (progressive disease) * A wash-out period off treatment of 2 weeks from last chemotherapy and 4 weeks from last immunotherapy, other systemic treatment with a biologic agent, or monoclonal antibody therapy will be required in individuals with prior KS therapy. * Resolution of toxicity from prior therapy to \<= Grade 1. * At least five measurable cutaneous KS lesions with no previous local radiation, surgical or intralesional cytotoxic therapy that would prevent response assessment for that lesion. * Measurable disease by the criteria proposed by the AIDS Clinical Trials Group (ACTG) Oncology Committee for KS * HIV positive or negative. * ART for HIV+ individuals for 8 or more weeks prior to entry with an HIV viral load of \<400 copies/ml at screening and CD4+ T cell count of \>= 50 cells/microliter as this may be expected if individuals have received several courses of chemotherapy. * Age \>=18 years. * ECOG performance status \<=2 (Karnofsky \>=60%). * Adequate organ and marrow function as defined below: * Absolute neutrophil count \>=1,000/mcL * Platelets \>=100,000/mcL * Total bilirubin within normal institutional limits; OR \<3x institutional ULN for Gilbert s syndrome or HIV protease inhibitors; OR \<5x ULN and direct bilirubin \< 0.7mg/dL for individuals on atazanavir-containing HIV regimen * AST(SGOT)/ALT(SGPT) \<=1.5 X institutional upper limit of normal * Hemoglobin \>= 9g/dL * Creatinine within normal institutional limits OR creatinine clearance \>30 mL/min/1.73m\^2 as estimated by either Cockroft-Gault of 24- hour urine collection if creatinine levels above institutional normal * Normal international normalized ratio (INR), PT\<=1.5 x ULN and activated partial thromboplastin time (aPTT) \<= 1.5 x ULN * The effects of PDS01ADC and M7824 on the developing human fetus are unknown. For this reason, individuals of child-bearing potential (IOCBP) and individuals able to father a child must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, during treatment and for at least 4 months after the last dose of treatment and agree to inform the treating physician immediately if they become pregnant. Also, there is unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with M7824 and/or PDS01ADC, therefore IOCBP must agree to discontinue nursing if treated with these agents. * Ability of individual to understand and the willingness to sign a written informed consent document.	* Receiving any other investigational agents. * Pregnant individuals are excluded from this study as the effects of PDS01ADC and M7824 have potential teratogenic or abortifacient effects. * Severe KS (such as symptomatic pulmonary KS) that could be life threatening if it progressed over 2-4 weeks * Actively bleeding sites caused by visceral KS. * Unwilling to accept blood products as medically indicated * Actively bleeding and/or requiring transfusions in the 2 weeks preceding study entry. * History of bleeding, diathesis, or recent major bleeding events within a period of 4 weeks considered by the investigator as high risk for investigational drug treatment. * Any active or recent history (symptomatic in the last 3 months) of a known or suspected autoimmune disease (with the exception of diabetes type I, vitiligo, psoriasis, or hypo- or hyperthyroid diseases not requiring immunosuppressive treatment) or recent history of a syndrome that required systemic corticosteroids (10mg daily prednisone or equivalent) or immunosuppressive medications except inhaled steroids and adrenal replacement steroids doses up to 10mg daily prednisone equivalents are permitted in the absence of active autoimmune disease. * Uncontrolled opportunistic infections * Active multicentric Castleman disease * Individuals with primary effusion lymphoma * History of malignant tumors other than KS, unless: * In complete remission for \>= 3 years from the time complete remission was first documented or * Resected basal cell or squamous cell carcinoma of the skin or * In situ cervical or anal dysplasia * History of allergic reactions attributed to compounds of similar chemical or biologic composition to PDS01ADC and/or M7824 investigational agents used in study. * Active tuberculosis (TB): * Individuals who are undergoing first month of therapy (RIPE or equivalent) for active TB or * Individuals with TB immune reconstitution syndrome (IRIS) requiring corticosteroids * Received or will receive a live vaccine within 30 days prior to the first administration of study intervention. Seasonal flu vaccines that do not contain a live virus are permitted. Locally approved COVID vaccines are permitted. * Uncontrolled substantial intercurrent illness including, but not limited to, ongoing or active severe infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, that would limit compliance with study requirements. * Medical or psychiatric illness or social situation that would, in the opinion of the investigator, preclude participation in the study or the ability of individuals to provide informed consent for themselves. * Uncontrolled HBV infection, defined as plasma HBV DNA detectable by PCR * A positive hepatitis B serology indicative of previous immunization (i.e. HbsAb positive and HbcAb negative), or a fully resolved acute HBV infection * Chronic HBV suppressed by appropriate antiretroviral therapy with activity against HBV, as outlined in DHHS guidelines. * Uncontrolled HCV infection, defined as plasma HCV DNA detectable by PCR * Positive HCV serology but no detectable HCV RNA, indicative of spontaneously cleared HCV infection * Successfully treated for HCV as long as therapy for HCV has been completed. * they have discontinued prior PD1/L1 blocking agent due to immune mediated adverse event(s) OR * they have active non-infectious pneumonitis or a history of steroid requiring non-infectious pneumonitis.

Inclusion Criteria

Exclusion Criteria

* Individuals with biopsy proven (confirmed in the Laboratory of Pathology, CCR) Kaposi sarcoma (KS)
* KS requiring systemic therapy, with or without history of prior KS therapy:
* T1 KS or T0 KS sufficiently widespread that systemic therapy is advisable, or KS affecting quality-of-life due to local symptoms or psychological distress
* KS with an inadequate response to liposomal doxorubicin, paclitaxel, other systemic chemotherapy (either progressive disease or stable disease after 3 or more cycles) or immunotherapy (progressive disease)
* A wash-out period off treatment of 2 weeks from last chemotherapy and 4 weeks from last immunotherapy, other systemic treatment with a biologic agent, or monoclonal antibody therapy will be required in individuals with prior KS therapy.
* Resolution of toxicity from prior therapy to \<= Grade 1.
* At least five measurable cutaneous KS lesions with no previous local radiation, surgical or intralesional cytotoxic therapy that would prevent response assessment for that lesion.
* Measurable disease by the criteria proposed by the AIDS Clinical Trials Group (ACTG) Oncology Committee for KS
* HIV positive or negative.
* ART for HIV+ individuals for 8 or more weeks prior to entry with an HIV viral load of \<400 copies/ml at screening and CD4+ T cell count of \>= 50 cells/microliter as this may be expected if individuals have received several courses of chemotherapy.
* Age \>=18 years.
* ECOG performance status \<=2 (Karnofsky \>=60%).
* Adequate organ and marrow function as defined below:
* Absolute neutrophil count \>=1,000/mcL
* Platelets \>=100,000/mcL
* Total bilirubin within normal institutional limits; OR \<3x institutional ULN for Gilbert s syndrome or HIV protease inhibitors; OR \<5x ULN and direct bilirubin \< 0.7mg/dL for individuals on atazanavir-containing HIV regimen
* AST(SGOT)/ALT(SGPT) \<=1.5 X institutional upper limit of normal
* Hemoglobin \>= 9g/dL
* Creatinine within normal institutional limits OR creatinine clearance \>30 mL/min/1.73m\^2 as estimated by either Cockroft-Gault of 24- hour urine collection if creatinine levels above institutional normal
* Normal international normalized ratio (INR), PT\<=1.5 x ULN and activated partial thromboplastin time (aPTT) \<= 1.5 x ULN
* The effects of PDS01ADC and M7824 on the developing human fetus are unknown. For this reason, individuals of child-bearing potential (IOCBP) and individuals able to father a child must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, during treatment and for at least 4 months after the last dose of treatment and agree to inform the treating physician immediately if they become pregnant. Also, there is unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with M7824 and/or PDS01ADC, therefore IOCBP must agree to discontinue nursing if treated with these agents.
* Ability of individual to understand and the willingness to sign a written informed consent document.

* Receiving any other investigational agents.
* Pregnant individuals are excluded from this study as the effects of PDS01ADC and M7824 have potential teratogenic or abortifacient effects.
* Severe KS (such as symptomatic pulmonary KS) that could be life threatening if it progressed over 2-4 weeks
* Actively bleeding sites caused by visceral KS.
* Unwilling to accept blood products as medically indicated
* Actively bleeding and/or requiring transfusions in the 2 weeks preceding study entry.
* History of bleeding, diathesis, or recent major bleeding events within a period of 4 weeks considered by the investigator as high risk for investigational drug treatment.
* Any active or recent history (symptomatic in the last 3 months) of a known or suspected autoimmune disease (with the exception of diabetes type I, vitiligo, psoriasis, or hypo- or hyperthyroid diseases not requiring immunosuppressive treatment) or recent history of a syndrome that required systemic corticosteroids (10mg daily prednisone or equivalent) or immunosuppressive medications except inhaled steroids and adrenal replacement steroids doses up to 10mg daily prednisone equivalents are permitted in the absence of active autoimmune disease.
* Uncontrolled opportunistic infections
* Active multicentric Castleman disease
* Individuals with primary effusion lymphoma
* History of malignant tumors other than KS, unless:
* In complete remission for \>= 3 years from the time complete remission was first documented or
* Resected basal cell or squamous cell carcinoma of the skin or
* In situ cervical or anal dysplasia
* History of allergic reactions attributed to compounds of similar chemical or biologic composition to PDS01ADC and/or M7824 investigational agents used in study.
* Active tuberculosis (TB):
* Individuals who are undergoing first month of therapy (RIPE or equivalent) for active TB or
* Individuals with TB immune reconstitution syndrome (IRIS) requiring corticosteroids
* Received or will receive a live vaccine within 30 days prior to the first administration of study intervention. Seasonal flu vaccines that do not contain a live virus are permitted. Locally approved COVID vaccines are permitted.
* Uncontrolled substantial intercurrent illness including, but not limited to, ongoing or active severe infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, that would limit compliance with study requirements.
* Medical or psychiatric illness or social situation that would, in the opinion of the investigator, preclude participation in the study or the ability of individuals to provide informed consent for themselves.
* Uncontrolled HBV infection, defined as plasma HBV DNA detectable by PCR
* A positive hepatitis B serology indicative of previous immunization (i.e. HbsAb positive and HbcAb negative), or a fully resolved acute HBV infection
* Chronic HBV suppressed by appropriate antiretroviral therapy with activity against HBV, as outlined in DHHS guidelines.
* Uncontrolled HCV infection, defined as plasma HCV DNA detectable by PCR
* Positive HCV serology but no detectable HCV RNA, indicative of spontaneously cleared HCV infection
* Successfully treated for HCV as long as therapy for HCV has been completed.
* they have discontinued prior PD1/L1 blocking agent due to immune mediated adverse event(s) OR
* they have active non-infectious pneumonitis or a history of steroid requiring non-infectious pneumonitis.

Contacts and Locations

Study Contact

Irene Ekwede, R.N.

CONTACT

(240) 760-6126

irene.ekwede@nih.gov

Ramya M Ramaswami, M.D.

CONTACT

(240) 506-1088

ramya.ramaswami@nih.gov

Principal Investigator

Ramya M Ramaswami, M.D.

PRINCIPAL_INVESTIGATOR

National Cancer Institute (NCI)

Study Locations (Sites)

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892

United States

Collaborators and Investigators

Sponsor: National Cancer Institute (NCI)

Ramya M Ramaswami, M.D., PRINCIPAL_INVESTIGATOR, National Cancer Institute (NCI)

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-07-13

Study Completion Date2028-12-01

Study Record Updates

Study Start Date2020-07-13

Study Completion Date2028-12-01

Terms related to this study

Keywords Provided by Researchers

Immune Therapy
AIDS
HIV
Immunocytokine

Additional Relevant MeSH Terms

Kaposi Sarcoma