Opioid, HIV and Immune System

Description

The purpose of this research is to evaluate blood samples from HIV infected and non-HIV infected people opioid and non opioid users to understand how opioid affect the immune responses (body defenses against infection) to the flu vaccine.

Conditions

Immune Defect

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Study Overview

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Study Details

Study overview

The purpose of this research is to evaluate blood samples from HIV infected and non-HIV infected people opioid and non opioid users to understand how opioid affect the immune responses (body defenses against infection) to the flu vaccine.

Immune Dysfunction in HIV+ Opioid Users

Opioid, HIV and Immune System

Condition
Immune Defect
Intervention / Treatment

-

Contacts and Locations

Miami

University of Miami, Miami, Florida, United States, 33136

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. OP users - prescribed opioids for at least the past 90 days; or injecting opioids for at least 90 days
  • 2. Opioid never-users in the past year
  • 1. OP use for 90 days pre-flu vaccination
  • 2. Continued OP use for 4 weeks post flu vaccination
  • 1. On ART for at least 1 year with plasma pending viral load (VL) \<200 copies/mL. Occasional viral blips up to 1000 copies/ml also acceptable provided the patients are on continuing treatment
  • 2. CD4 count available in the prior 6 months and \>200/mm3
  • 3. Undetectable viral load (\< 200 copies/mL)
  • 1. Individuals age 18-60 yrs .
  • 2. No history of other immunodeficiency disorders
  • 3. Not on steroid or other immunosuppressive/immunomodulators medications.
  • 4. No active malignancies.
  • 5. No contraindication to receive influenza vaccination (allergy to chicken eggs or to any other substance of the vaccine).
  • 6. Agreeable to receive the influenza vaccination.
  • 7. Agreeable to participate in study for a complete course of study full visits.
  • 8. Able to provide informed consent.
  • 1. Contraindication to receive influenza vaccination (allergy to chicken eggs or to any other substance of the vaccine).
  • 2. Non-adherence to ART for HIV+
  • 3. Unable to provide informed consent.
  • 4. Other comorbid conditions such as diabetes mellitus type 2 (DMT2)
  • 5. Influenza vaccination already given during the current vaccination season.

Ages Eligible for Study

18 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Miami,

Savita Pahwa, MD, PRINCIPAL_INVESTIGATOR, University of Miami

Study Record Dates

2025-05-31