Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke

Description

This study will examine the combination of myoelectric computer interface (MyoCI) training with targeted memory reactivation (TMR) in chronic stroke survivors. The study aims to determine whether this training-plus-sleep combination will generalize to improve arm motor function over an extended training protocol in stroke survivors.

Conditions

Stroke

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Study Overview

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Study Details

Study overview

This study will examine the combination of myoelectric computer interface (MyoCI) training with targeted memory reactivation (TMR) in chronic stroke survivors. The study aims to determine whether this training-plus-sleep combination will generalize to improve arm motor function over an extended training protocol in stroke survivors.

Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke

Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke

Condition
Stroke
Intervention / Treatment

-

Contacts and Locations

Chicago

Northwestern University, Chicago, Illinois, United States, 60611

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age at enrollment is 21 or older
  • * Hemiparesis from first ever stroke affecting arm movement at least 6 months prior to screening
  • * Severe to moderate motor impairment (FMA-UE of 7-40)
  • * At least some voluntary shoulder and elbow muscle activation
  • * Inability to follow instructions of the MyoCI task
  • * Visual impairment (such as hemianopia) preventing full view of screen
  • * Anesthesia or neglect in the affected arm, or visual hemineglect (score of 2 on the NIH Stroke Scale Extinction and Inattention subtest)
  • * Participation in another study on the affected arm within 6 weeks of enrollment or any pharmacological study
  • * Inability to understand or follow commands in English due to aphasia or other reason
  • * Diffuse or multifocal infarcts in both hemispheres
  • * Substantial arm pain preventing participation for 90 minutes a day
  • * Spasticity treatment (pharmacological or Botox) within last 3 months
  • * Ferromagnetic implants that are MRI incompatible

Ages Eligible for Study

21 Years to 100 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Northwestern University,

Marc W Slutzky, MD/PhD, PRINCIPAL_INVESTIGATOR, Northwestern University

Study Record Dates

2025-08-30