RECRUITING

Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The focus of this proposal is on overweight (25\>BMI\<30 kg/m2) subjects, as these individuals exhibit a high risk of becoming obese and/or developing metabolic diseases. We hypothesize that in some overweight individuals there is a "metabolic program" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.

Official Title

Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis

Quick Facts

Study Start:2020-03-03
Study Completion:2024-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04320264

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * 18-50 years old
  2. * BMI of 25 - 30 kg/m2
  3. * BMI \> 40kg/m2
  4. * Lactate levels in top and lower 25%
  1. * Pregnant women
  2. * Mentally disabled
  3. * Prisoners
  4. * Smokers
  5. * Subjects with heart disease
  6. * Type 1 and 2 diabetes
  7. * Endocrine disease
  8. * Hypertension
  9. * Musculoskeletal disease
  10. * Peripheral occlusion
  11. * Hepatic disease
  12. * Have had weight fluctuations exceeding + 3% in the previous 12 months
  13. * On medications which alter carbohydrate metabolism will not be studied

Contacts and Locations

Study Contact

Terry Jones, PhD
CONTACT
2527446249
joneste@ecu.edu
Nicholas Broskey, PhD
CONTACT
2527374684
broskeyn19@ecu.edu

Principal Investigator

Joseph Houmard, PhD
PRINCIPAL_INVESTIGATOR
East Carolina University

Study Locations (Sites)

East Carolina University
Greenville, North Carolina, 27834
United States

Collaborators and Investigators

Sponsor: East Carolina University

  • Joseph Houmard, PhD, PRINCIPAL_INVESTIGATOR, East Carolina University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-03-03
Study Completion Date2024-12

Study Record Updates

Study Start Date2020-03-03
Study Completion Date2024-12

Terms related to this study

Keywords Provided by Researchers

  • Metabolic Inflexibility
  • Obesity
  • Anaerobic glycolysis

Additional Relevant MeSH Terms

  • Metabolic Inflexibility