Comparative Effectiveness of CET vs. SST in SMI (Serious Mental Illness)

Description

To compare two evidence-based treatments, Cognitive Enhancement Therapy (CET) and Social Skills Training (SST) that have been shown in meta-analyses and in our own research to be effective to improve community functioning. The investigators will test the impact of CET and SST on community functioning, with special attention to their relative effectiveness for patients differing in baseline cognitive skills and age. The research uses a cluster design in which different mental health service centers are randomized to one of the two treatments.

Conditions

Schizophrenia and Related Disorders

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Study Overview

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Study Details

Study overview

To compare two evidence-based treatments, Cognitive Enhancement Therapy (CET) and Social Skills Training (SST) that have been shown in meta-analyses and in our own research to be effective to improve community functioning. The investigators will test the impact of CET and SST on community functioning, with special attention to their relative effectiveness for patients differing in baseline cognitive skills and age. The research uses a cluster design in which different mental health service centers are randomized to one of the two treatments.

Comparative Effectiveness of Cognitive Enhancement Therapy vs. Social Skills Training in Serious Mental Illness

Comparative Effectiveness of CET vs. SST in SMI (Serious Mental Illness)

Condition
Schizophrenia and Related Disorders
Intervention / Treatment

-

Contacts and Locations

Hartford

Hartford Hospital - Institute of Living, Hartford, Connecticut, United States, 06106

Portland

Maine Medical Center, Portland, Maine, United States, 04102

Boston

Massachusetts Mental Health Center, Boston, Massachusetts, United States, 02115

Boston

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States, 02215

Worcester

UMass Medical School, Worcester, Massachusetts, United States, 01603

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. age 18 to 65;
  • 2. DSM-5 diagnosis of schizophrenia or schizoaffective or schizophreniform disorder (confirmed via the MINI diagnostic interview);
  • 3. estimated IQ of \> 70 (established via WTAR).
  • 1. the presence of a current organic brain syndrome;
  • 2. intellectual disability (DSM-5);
  • 3. participation in either CET or SST within the prior year.

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Beth Israel Deaconess Medical Center,

Matcheri S Keshavan, MD, PRINCIPAL_INVESTIGATOR, Beth Israel Deaconess Medical Center

Russell K Schutt, PhD, PRINCIPAL_INVESTIGATOR, Beth Israel Deaconess Medical Center

Study Record Dates

2026-01-31